ENSG00000172238


Homo sapiens

Features
Gene ID: ENSG00000172238
  
Biological name :ATOH1
  
Synonyms : ATOH1 / atonal bHLH transcription factor 1 / Q92858
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.2
Gene start: 93828753
Gene end: 93830964
  
Corresponding Affymetrix probe sets: 221336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302216
NCBI entrez gene - 474     See in Manteia.
OMIM - 601461
RefSeq - NM_005172
RefSeq Peptide - NP_005163
swissprot - Q92858
Ensembl - ENSG00000172238
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atoh1aENSDARG00000055294Danio rerio
 1 ENSMUSG00000073043Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H2A3 / NEUROG2 / neurogenin 2ENSG0000017840319
Q92886 / NEUROG1 / neurogenin 1ENSG0000018196517
Q9HD90 / NEUROD4 / neuronal differentiation 4ENSG0000012330716
ATOH7 / Q8N100 / atonal bHLH transcription factor 7ENSG0000017977416
Q15784 / NEUROD2 / neuronal differentiation 2ENSG0000017153215
ATOH8 / Q96SQ7 / atonal bHLH transcription factor 8ENSG0000016887415
Q96NK8 / NEUROD6 / neuronal differentiation 6ENSG0000016460014
Q7RTS1 / BHLHA15 / basic helix-loop-helix family member a15ENSG0000018053514
Q13562 / NEUROD1 / neuronal differentiation 1ENSG0000016299214
Q9Y4Z2 / NEUROG3 / neurogenin 3ENSG0000012285913


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032661  Protein atonal homologue 1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IEA
 biological_processGO:0042667 auditory receptor cell fate specification IEA
 biological_processGO:0042668 auditory receptor cell fate determination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045609 positive regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:2000982 positive regulation of inner ear receptor cell differentiation IEA
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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