ENSG00000162992


Homo sapiens

Features
Gene ID: ENSG00000162992
  
Biological name :NEUROD1
  
Synonyms : NEUROD1 / neuronal differentiation 1 / Q13562
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q31.3
Gene start: 181673088
Gene end: 181680876
  
Corresponding Affymetrix probe sets: 1556057_s_at (Human Genome U133 Plus 2.0 Array)   206282_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295108
RefSeq - NM_002500
RefSeq Peptide - NP_002491
swissprot - A0A0S2Z493
swissprot - Q13562
Ensembl - ENSG00000162992
  

This gene has been taged as a transcription factor by TFT
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O42202ENSDARG00000019566Danio rerio
 NEUROD1ENSGALG00000008908Gallus gallus
 Q60867ENSMUSG00000034701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15784 / NEUROD2 / neuronal differentiation 2ENSG0000017153253
Q9HD90 / NEUROD4 / neuronal differentiation 4ENSG0000012330750
Q96NK8 / NEUROD6 / neuronal differentiation 6ENSG0000016460048
Q92886 / NEUROG1 / neurogenin 1ENSG0000018196519
Q9Y4Z2 / NEUROG3 / neurogenin 3ENSG0000012285916
Q9H2A3 / NEUROG2 / neurogenin 2ENSG0000017840316
ATOH1 / Q92858 / atonal bHLH transcription factor 1ENSG0000017223814
ATOH8 / Q96SQ7 / atonal bHLH transcription factor 8ENSG0000016887414
Q7RTS1 / BHLHA15 / basic helix-loop-helix family member a15ENSG0000018053513
ATOH7 / Q8N100 / atonal bHLH transcription factor 7ENSG0000017977412


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR016637  Neurogenic differentiation factor NeuroD
 IPR022575  Neurogenic differentiation factor, domain of unknown function
 IPR032652  Neurogenic differentiation factor 1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003326 pancreatic A cell fate commitment IEA
 biological_processGO:0003329 pancreatic PP cell fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0021542 dentate gyrus development ISS
 biological_processGO:0021549 cerebellum development ISS
 biological_processGO:0022008 neurogenesis TAS
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030073 insulin secretion IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0031018 endocrine pancreas development ISS
 biological_processGO:0035881 amacrine cell differentiation ISS
 biological_processGO:0035883 enteroendocrine cell differentiation ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045597 positive regulation of cell differentiation ISS
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0048562 embryonic organ morphogenesis ISS
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048839 inner ear development ISS
 biological_processGO:0050796 regulation of insulin secretion IC
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060730 regulation of intestinal epithelial structure maintenance ISS
 biological_processGO:0071156 regulation of cell cycle arrest ISS
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:2000675 negative regulation of type B pancreatic cell apoptotic process ISS
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
Regulation of gene expression in beta cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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