Manteia

ENSMUSG00000034701

Mus musculus

Features

Gene ID:	ENSMUSG00000034701

Biological name :	Neurod1

Synonyms :	Neurod1 / Neurogenic differentiation factor 1 / Q60867

Possible biological names infered from orthology :	neuronal differentiation 1 / Q13562

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	C3
Gene start:	79452521
Gene end:	79456751

Corresponding Affymetrix probe sets:	10484276 (MoGene1.0st) 1426412_at (Mouse Genome 430 2.0 Array) 1426413_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000040364 NCBI entrez gene - 18012 See in Manteia. MGI - MGI:1339708 RefSeq - NM_010894 RefSeq Peptide - NP_035024 swissprot - Q60867 Ensembl - ENSMUSG00000034701

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
O42202	ENSDARG00000019566	Danio rerio
NEUROD1	ENSGALG00000008908	Gallus gallus
Q13562	ENSG00000162992	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*	ENSMUSG00000038255	54
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*	ENSMUSG00000048015	50
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*	ENSMUSG00000037984	47
P70660 / Neurog1 / Neurogenin-1 / Q92886*	ENSMUSG00000048904	19
Neurog2 / neurogenin 2 / Q9H2A3*	ENSMUSG00000027967	17
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*	ENSMUSG00000044312	16
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*	ENSMUSG00000073043	15
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*	ENSMUSG00000037621	14
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*	ENSMUSG00000052271	13
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*	ENSMUSG00000036816	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637	Neurogenic differentiation factor NeuroD
IPR022575	Neurogenic differentiation factor, domain of unknown function
IPR032652	Neurogenic differentiation factor 1
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003326	pancreatic A cell fate commitment	IGI
biological_process	GO:0003329	pancreatic PP cell fate commitment	IGI
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006913	nucleocytoplasmic transport	IEA
biological_process	GO:0007263	nitric oxide mediated signal transduction	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0009749	response to glucose	IEA
biological_process	GO:0009952	anterior/posterior pattern specification	IMP
biological_process	GO:0021542	dentate gyrus development	IMP
biological_process	GO:0021549	cerebellum development	IEA
biological_process	GO:0023019	signal transduction involved in regulation of gene expression	IDA
biological_process	GO:0030073	insulin secretion	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030902	hindbrain development	IMP
biological_process	GO:0031018	endocrine pancreas development	IMP
biological_process	GO:0035881	amacrine cell differentiation	IDA
biological_process	GO:0035883	enteroendocrine cell differentiation	IMP
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042593	glucose homeostasis	IMP
biological_process	GO:0043010	camera-type eye development	IGI
biological_process	GO:0043065	positive regulation of apoptotic process	IDA
biological_process	GO:0045165	cell fate commitment	IGI
biological_process	GO:0045597	positive regulation of cell differentiation	IDA
biological_process	GO:0045664	regulation of neuron differentiation	IGI
biological_process	GO:0045666	positive regulation of neuron differentiation	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046426	negative regulation of JAK-STAT cascade	IDA
biological_process	GO:0048562	embryonic organ morphogenesis	IMP
biological_process	GO:0048666	neuron development	IEA
biological_process	GO:0048839	inner ear development	IMP
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0060730	regulation of intestinal epithelial structure maintenance	IDA
biological_process	GO:0071156	regulation of cell cycle arrest	IMP
biological_process	GO:0071333	cellular response to glucose stimulus	IEA
biological_process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	IMP
biological_process	GO:2000679	positive regulation of transcription regulatory region DNA binding	IEA
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001102	RNA polymerase II activating transcription factor binding	IEA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003690	double-stranded DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003713	transcription coactivator activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA
molecular_function	GO:0070888	E-box binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000436	abnormal head movements	"anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atp7a^Mo-ms/Y Genetic Background: involves: CBA/Kw
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0000808	abnormal hippocampus development	"improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0000814	absent dentate gyrus	"lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000873	thin external granule cell layer	"reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000886	abnormal cerebellar granule layer	"any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000951	sporadic seizures	"occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atp7a^Mo-ms/Y Genetic Background: involves: CBA/Kw
MP:0000966	reduced sensory neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan,Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0001006	abnormal cone morphology	"structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0001183	overexpanded alveoli	"expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0001327	reduced retinal photoreceptor cell number	"fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wnt9b^clf1/Wnt9b^clf1,clf2/clf2⁺ Genetic Background: AEJ.A/Jur Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR) or (involves: 129S2/SvPas * 129S4/SvJaeSor * ICR) Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt9b^clf1/Wnt9b^clf1,clf2/clf2⁺ Genetic Background: AEJ.A/Jur Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan,Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J Allelic Composition: Neurod1^m1Btlr/Neurod1^m1Btlr Genetic Background: C57BL/6J-Neurod1^m1Btlr
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atp7a^Mo-ms/Y Genetic Background: involves: CBA/Kw
MP:0002578	impaired ability to fire action potentials	"anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0002856	abnormal vestibular ganglion morphology	"malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0002893	ketoaciduria	"excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0002983	increased retinal ganglion cell number	"greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0003146	absent cochlear ganglion	"absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [J:36834, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0003310	reduced modiolus	"a reduction in the volume of the central conical bony pillar of the cochlea" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66787]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0003339	decreased number of pancreatic beta cells	"fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0003727	abnormal retinal layer morphology	"malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003728	abnormal photoreceptor layer	"malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003731	abnormal outer nuclear layer morphology	"malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0004021	abnormal rod electrophysiology	"anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan,Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0004410	absent endocochlear potential	"absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0004994	abnormal brain wave pattern	"any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0005191	head tilt	"condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0005217	abnormal pancreatic beta cell morphology	"malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0005240	abnormal amacrine cell morphology	"anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005241	abnormal retinal ganglion layer morphology	"anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Wnt9b^clf1/Wnt9b^clf1,clf2/clf2⁺ Genetic Background: AEJ.A/Jur Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^m1Btlr/Neurod1^m1Btlr Genetic Background: C57BL/6J-Neurod1^m1Btlr
MP:0005547	abnormal Muller cell morphology	"anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
MP:0006068	abnormal horizontal cell morphology	"anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006069	abnormal retinal neuronal layer morphology	"malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006072	abnormal retinal apoptosis	"increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0006073	abnormal retinal bipolar cell morphology	"anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006095	absent amacrine cells	"absence or loss of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:74753]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * ICR
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan,Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0006382	abnormal lung epithelium morphology	"any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
MP:0008056	abnormal retinal ganglion cell morphology	"any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk} Genetic Background: Not Specified
MP:0008106	decreased amacrine cell number	"reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008269	abnormal hippocampus CA4 region morphology		Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0008285	abnormal hippocampus granule cell layer		Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0008446	decreased retinal cone cell number	"reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008516	disorganized retinal outer nuclear layer	"derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0009146	abnormal pancreatic acinar cell morphology	"any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0009161	pancreatic acinar cell zymogen granule accumulation	"a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0009173	absent pancreatic islets	"absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0009177	decreased pancreatic alpha cell number	"reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0009181	decreased pancreatic delta cell number	"reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: a/A^y,Bwq2^KK/Bwq2^KK Genetic Background: involves: C57BL/6J * KK-A^y
MP:0009938	abnormal hippocampus granule cell morphology	"any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0010802	abnormal intestinal enteroendocrine cell morphology	"any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0010916	decreased solitary pulmonary neuroendocrine cell number	"decreased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
MP:0010919	increased number of pulmonary neuroendocrine bodies	"greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts,Neurod6^tm1Kan/Neurod6^tm1Kan Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^tm1Kan/Neurod1^tm1Kan Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Neurod1^tm1Kan/Neurod1^tm1Mjts Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR) or (involves: 129S2/SvPas * 129S4/SvJaeSor * ICR) Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0013220	increased pancreas apoptosis	"increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka Genetic Background: Not Specified
MP:0030005	increased retinal apoptosis	"increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle Genetic Background: involves: 129S4/SvJaeSor * ICR

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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