Manteia - Molecule gene

ENSMUSG00000027967

Mus musculus

Features

Gene ID:	ENSMUSG00000027967

Biological name :	Neurog2

Synonyms :	Neurog2 / neurogenin 2

Possible biological names infered from orthology :	Q9H2A3

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	G2
Gene start:	127633135
Gene end:	127635631

Corresponding Affymetrix probe sets:	10495964 (MoGene1.0st) 1422839_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000029587 NCBI entrez gene - 11924 See in Manteia. MGI - MGI:109619 RefSeq - NM_009718 RefSeq Peptide - NP_033848 swissprot - Q6GTH9 Ensembl - ENSMUSG00000027967

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
O42606	ENSDARG00000056130	Danio rerio
Q9H2A3	ENSG00000178403	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P70660 / Neurog1 / Neurogenin-1 / Q92886*	ENSMUSG00000048904	34
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*	ENSMUSG00000044312	31
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*	ENSMUSG00000037984	25
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*	ENSMUSG00000048015	24
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*	ENSMUSG00000073043	24
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*	ENSMUSG00000034701	23
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*	ENSMUSG00000038255	22
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*	ENSMUSG00000037621	17
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*	ENSMUSG00000052271	17
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*	ENSMUSG00000036816	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR032655	Neurogenin-2
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0030182	neuron differentiation	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129 * C57BL/6J * CD-1
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/Jcl
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hdac1^tm1Sei/Hdac1^tm1Sei Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1
MP:0000872	abnormal external granule cell layer	"malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/Jcl
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Hdac1^tm1Sei/Hdac1^tm1Sei Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129 * C57BL/6J * CD-1
MP:0000937	abnormal motor neuron morphology	"malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0000939	reduced motor neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Clec4a2^tm1Yiw/Clec4a2^tm1Yiw Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Neurog1^tm1And/Neurog1^tm1And,Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001034	abnormal parasympathetic ganglia morphology	"malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001071	abnormal facial nerve morphology	"malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001082	abnormal geniculate ganglion morphology	"malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001084	abnormal petrosal ganglion morphology	"malformation of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001327	reduced retinal photoreceptor cell number	"fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0002751	abnormal autonomic nervous system morphology	"any malformation or absence of neurons in the motor system for the viscera, the smooth muscles of the body or exocrine glands; includes the enteric, parasympathetic, and sympathetic nervous systems taken together" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0002752	abnormal somatic nervous system morphology	"malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0002983	increased retinal ganglion cell number	"greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003648	abnormal radial glial cell morphology	"anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1
MP:0003727	abnormal retinal layer morphology	"malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003728	abnormal photoreceptor layer	"malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003731	abnormal outer nuclear layer morphology	"malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0004100	abnormal spinal cord interneuron morphology	"malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^{tm3(Ascl1)Fgu}/Neurog2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^tm1.1Meg/Neurog2^tm1.1Meg Genetic Background: involves: 129
MP:0004263	abnormal limb posture	"atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1 Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: 129 * MF1
MP:0005547	abnormal Muller cell morphology	"anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1
MP:0006068	abnormal horizontal cell morphology	"anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006069	abnormal retinal neuronal layer morphology	"malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006073	abnormal retinal bipolar cell morphology	"anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008031	decreased Cajal-Retzius cell number	"reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itgb1^tm1Lscd/Itgb1^tm1Mll,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0008106	decreased amacrine cell number	"reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008446	decreased retinal cone cell number	"reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0008516	disorganized retinal outer nuclear layer	"derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac1^tm1Sei/Hdac1^tm1Sei Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6) Allelic Composition: Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^{tm5(Neurog2)Fgu}/Neurog2^{tm5(Neurog2)Fgu} Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Npy1r^tm1Tped/Npy1r^tm1Tped Genetic Background: B6.129P2-Npy1r^tm1Tped Allelic Composition: Neurog2^tm4Fgu/Neurog2^tm4Fgu Genetic Background: involves: MF1
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Neurog2^tm2Fgu/Neurog2^tm2Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR Allelic Composition: Ascl1^tm1And/Ascl1^tm1And,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR Allelic Composition: Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
MP:0030005	increased retinal apoptosis	"increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Neurod1^tm1Jle/Neurod1^tm1Jle,Neurod4^tm1Kag/Neurod4^tm1Kag,Neurog2^tm1Fgu/Neurog2^tm1Fgu Genetic Background: involves: 129/Sv * C57BL/6 * CBA * ICR

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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