ENSMUSG00000073043


Mus musculus

Features
Gene ID: ENSMUSG00000073043
  
Biological name :Atoh1
  
Synonyms : 1 / Atoh1 / P48985
  
Possible biological names infered from orthology : atonal bHLH transcription factor 1 / Q92858
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 64729125
Gene end: 64731245
  
Corresponding Affymetrix probe sets: 10538751 (MoGene1.0st)   1449822_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098903
NCBI entrez gene - 11921     See in Manteia.
MGI - MGI:104654
RefSeq - NM_007500
RefSeq Peptide - NP_031526
swissprot - P48985
Ensembl - ENSMUSG00000073043
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atoh1aENSDARG00000055294Danio rerio
 ATOH1ENSG00000172238Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796718
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890417
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470115
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681615
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801515
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825515
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798414
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762114
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227114
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431213


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032661  Protein atonal homologue 1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IMP
 biological_processGO:0042667 auditory receptor cell fate specification IMP
 biological_processGO:0042668 auditory receptor cell fate determination IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045609 positive regulation of inner ear auditory receptor cell differentiation IDA
 biological_processGO:0045664 regulation of neuron differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:2000982 positive regulation of inner ear receptor cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000874 irregular external granule cell layer "uneven thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: A.B6-Prf1tm1Sdz

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
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Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: A.B6-Prf1tm1Sdz

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: A.B6-Prf1tm1Sdz

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,Tg(n-TRtct5)574Slac/0
Genetic Background: involves: C57BL/6J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002623 abnormal vestibular hair cell morphology "malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,Tg(n-TRtct5)574Slac/0
Genetic Background: involves: C57BL/6J

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0003380 abnormal intestine regeneration "deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Selltm1Alb/Selltm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Selltm1Alb/Selltm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Selltm1Alb/Selltm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo
Genetic Background: Not Specified

Allelic Composition: Atoh1tm2Hzo/Atoh1tm3.1Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL

Allelic Composition: Atoh1tm1(cre)Gan/Atoh1tm1(cre)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Atoh1trhl/Atoh1trhl
Genetic Background: B6.Cg-Atoh1trhl

 MP:0012490 abnormal cochlear VIII nucleus morphology "any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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