ENSMUSG00000038255


Mus musculus

Features
Gene ID: ENSMUSG00000038255
  
Biological name :Neurod2
  
Synonyms : Neurod2 / neurogenic differentiation 2 / Q62414
  
Possible biological names infered from orthology : neuronal differentiation 2 / Q15784
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98325415
Gene end: 98329648
  
Corresponding Affymetrix probe sets: 10390618 (MoGene1.0st)   1418995_at (Mouse Genome 430 2.0 Array)   1435411_at (Mouse Genome 430 2.0 Array)   1444362_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041373
NCBI entrez gene - 18013     See in Manteia.
MGI - MGI:107755
RefSeq - NM_010895
RefSeq Peptide - NP_035025
swissprot - Q3TYB2
swissprot - Q62414
Ensembl - ENSMUSG00000038255
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurod2ENSDARG00000016854Danio rerio
 NEUROD2ENSGALG00000039633Gallus gallus
 Q15784ENSG00000171532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470150
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798444
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801537
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890418
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796715
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431215
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762115
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304314
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227114
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681611


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR016637  Neurogenic differentiation factor NeuroD
 IPR022575  Neurogenic differentiation factor, domain of unknown function
 IPR032649  Neurogenic differentiation factor 2
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0021695 cerebellar cortex development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IDA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0071257 cellular response to electrical stimulus IDA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0090128 regulation of synapse maturation IEA
 biological_processGO:0090129 positive regulation of synapse maturation IMP
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000297 negative regulation of synapse maturation IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Runx1tm1Spe/Runx1tm2Spe
Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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