ENSMUSG00000037984


Mus musculus

Features
Gene ID: ENSMUSG00000037984
  
Biological name :Neurod6
  
Synonyms : Neurod6 / neurogenic differentiation 6 / P48986
  
Possible biological names infered from orthology : neuronal differentiation 6 / Q96NK8
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 55677822
Gene end: 55681263
  
Corresponding Affymetrix probe sets: 10544936 (MoGene1.0st)   1418047_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047016
NCBI entrez gene - 11922     See in Manteia.
MGI - MGI:106593
RefSeq - NM_009717
RefSeq Peptide - NP_033847
swissprot - P48986
swissprot - Q5M8T7
Ensembl - ENSMUSG00000037984
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NYU3ENSDARG00000040008Danio rerio
 Q9W6C7ENSDARG00000020794Danio rerio
 Q96NK8ENSG00000164600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470150
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825550
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801540
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796719
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890419
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431219
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227115
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762114
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304314
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681612


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR016637  Neurogenic differentiation factor NeuroD
 IPR022575  Neurogenic differentiation factor, domain of unknown function
 IPR032650  Neurogenic differentiation factor 6
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021542 dentate gyrus development IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Smotm1Amc/Smotm2Amc,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Grin2btm1.1Jlbr/Grin2btm1.1Jlbr,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Grin2btm1.1Jlbr/Grin2btm1.1Jlbr,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Grin2btm1.1(Grin2a)Bjha/Grin2btm1.1(Grin2a)Bjha
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Afu/Agttm1Afu,Tg(Fabp4-Agt)2Mte/0
Genetic Background: involves: C57BL/6 * CBA * DBA/2 * ICR

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Nedd4tm2Bros/Nedd4tm2Bros
Genetic Background: involves: C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nedd4tm3.1Bros/Nedd4tm3.1Bros,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * SJL

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N

 MP:0008285 abnormal hippocampus granule cell layer 
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0008443 absent subplate "absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Nedd4tm3.1Bros/Nedd4tm3.1Bros,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * SJL

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afdntm1.1Lfr/Afdntm1.1Lfr,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010011 ectopic hippocampus pyramidal cells "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afdntm1.1Lfr/Afdntm1.1Lfr,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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