ENSMUSG00000052271


Mus musculus

Features
Gene ID: ENSMUSG00000052271
  
Biological name :Bhlha15
  
Synonyms : Bhlha15 / Class A basic helix-loop-helix protein 15 / Q9QYC3
  
Possible biological names infered from orthology : basic helix-loop-helix family member a15 / Q7RTS1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 144190286
Gene end: 144194441
  
Corresponding Affymetrix probe sets: 10527323 (MoGene1.0st)   1418800_at (Mouse Genome 430 2.0 Array)   1449233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055493
NCBI entrez gene - 17341     See in Manteia.
MGI - MGI:891976
RefSeq - NM_010800
RefSeq - XM_006504808
RefSeq Peptide - NP_034930
swissprot - Q9QYC3
Ensembl - ENSMUSG00000052271
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bhlha15ENSDARG00000045166Danio rerio
 ENSGALG00000031306Gallus gallus
 Q7RTS1ENSG00000180535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825528
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304325
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798425
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890423
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796723
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801523
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470123
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431222
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762121
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681618


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002071 glandular epithelial cell maturation IC
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0010832 negative regulation of myotube differentiation IDA
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048312 intracellular distribution of mitochondria IMP
 biological_processGO:0048469 cell maturation IMP
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(BGLAP-cre)1Clem/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/NJ

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003334 pancreatic fibrosis "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008780 pancreatic acinar cell carcinoma "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009043 pancreas adenoma "a benign epithelial neoplasm located in the pancreas" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009147 abnormal pancreatic acinar cell physiology "any functional anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
Show

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Bhlha15tm3(cre/ERT2)Skz/Bhlha15+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009155 pancreatic acinar hyperplasia "overdevelopment or increased size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to an increased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009160 abnormal pancreatic acinar cell zymogen granule "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010172 abnormal mammary gland epithelium physiology "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
Show

Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013317 abnormal seminal vesicle development "aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus" [MGI:Anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0013594 abnormal parotid gland acinus morphology "any structural anomaly of any of the secretory units (acini) of either parotid gland which in human and rodent consist almost exclusively of serous secretory cells with their lumina continuous with intercalated ducts; in mouse, parotid gland acini are very small and consist of 3-4 tall pyramidal cells with strongly basophilic cytoplasm and basally located, large spherical nuclei; the serous secretory cells contain many secretory granules having an electron-lucent profile which are situated in the supranuclear cytoplasm; the serous secretory cells have a well-developed rough endoplasmic reticulum in the infranuclear region and are surrounded by myoepithelial cells" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, MGI:Anna, PMID:23209333]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0013781 abnormal mammary gland luminal epithelium morphology "any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, ISBN:8793237073, MGI:Anna]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013899 abnormal seminal vesicle epithelium morphology "any structural anomaly of the pseudostratified columnar epithelium that lines the seminal vesicles and consists of tall, non-ciliated columnar cells and short, rounded basal cells that rest on the basal lamina; polarized columnar cells show features typical of secretory epithelium, including a well-developed Golgi complex, abundant rough endoplasmic reticulum, numerous mitochondria, and apical secretory vesicles; basal cells are the stem cells from which the columnar cells are derived" [ISBN:0781767903, ISBN:1455703079, MGI:Anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0013900 seminal vesicle epithelium degeneration 
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0013903 abnormal seminal vesicle fluid composition "any alteration in the expected chemical makeup or appearance of the whitish yellow alkaline fluid secreted by the seminal vesicles that constitutes 60-70 percent of the ejaculate in humans; the secretory product of the columnar epithelial cell, which may be seen in the lumen of seminal vesicles, is strongly acidophilic; it contains large amounts of fructose (used by spermatozoa as an energy source for motility) in addition to water, K+ ions, phosphorylcholine, prostaglandins, flavins, citrate, ascorbic acid, and several amino acids and enzymes; seminal vesicle fluid is responsible for coagulation of the ejaculate, can alter sperm motility and capacitation, and acts as an immunosuppressant in the female reproductive tract" [http://www.lab.anhb.uwa.edu.au/mb140/corepages/malerepro/malerepro.htm#LabSeminal, https://en.wikipedia.org/wiki/Seminal_vesicle#Function, ISBN:0781767903, ISBN:1455703079, MGI:Anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0014098 decreased pancreatic amylase secretion "reduction in the production and/or release of alpha-amylase, the main starch digesting enzyme component of pancreatic juice, from the acinar cells of the exocrine pancreas; pancreatic alpha-amylase is released into pancreatic ducts in its active form and acts at random locations along the starch chain to break down long-chain carbohydrates, ultimately yielding maltotriose and maltose from amylose, or maltose, glucose and limit dextrin from amylopectin" [http://en.wikipedia.org/wiki/Amylase, http://www.newworldencyclopedia.org/entry/Pancreas]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Bhlha15tm1Skz/Bhlha15tm1Skz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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