ENSMUSG00000036816


Mus musculus

Features
Gene ID: ENSMUSG00000036816
  
Biological name :Atoh7
  
Synonyms : 7 / Atoh7 / Q9Z2E5
  
Possible biological names infered from orthology : atonal bHLH transcription factor 7 / Q8N100
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 63099651
Gene end: 63101279
  
Corresponding Affymetrix probe sets: 10363639 (MoGene1.0st)   1422929_s_at (Mouse Genome 430 2.0 Array)   1450796_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039801
NCBI entrez gene - 53404     See in Manteia.
MGI - MGI:1355553
RefSeq - NM_016864
RefSeq Peptide - NP_058560
swissprot - Q9Z2E5
Ensembl - ENSMUSG00000036816
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atoh7ENSDARG00000069552Danio rerio
 ATOH7ENSGALG00000003931Gallus gallus
 ATOH7ENSG00000179774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304336
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431230
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890429
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801529
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825529
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796728
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798428
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470126
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227124
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762123


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032663  Protein atonal homologue 7
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007623 circadian rhythm IMP
 biological_processGO:0009649 entrainment of circadian clock IMP
 biological_processGO:0021554 optic nerve development IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Neurod1tm1.1(Atoh7)Whk/Neurod1tm1.1(Atoh7)Whk
Genetic Background: Not Specified

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Resttm1.1Whk/Resttm1.1Whk,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Neurod1tm1.1(Atoh7)Whk/Neurod1tm1.1(Atoh7)Whk
Genetic Background: Not Specified

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)60Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

Allelic Composition: Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

 MP:0001334 absent optic tract "absence of the set of cell bodies and nerve fibers conducting impulses from the retina to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Neurod1tm1.1(Atoh7)Whk/Neurod1tm1.1(Atoh7)Whk
Genetic Background: Not Specified

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: Not Specified

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Fat3tm1.1Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006070 increased retinal photoreceptor number "greater than the expected number of rods and/or cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0006075 abnormal retinal cone bipolar cell morphology "anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)60Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm3(cre)Gan/Atoh7tm3(cre)Gan
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Neurod1tm1.1(Atoh7)Whk/Neurod1tm1.1(Atoh7)Whk
Genetic Background: Not Specified

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008068 absent retinal ganglion cell "absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008445 increased retinal cone cell number "greater number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7+,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008510 absent retinal ganglion layer "absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: B6.129-Atoh7tm1Gla

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: B6.129-Atoh7tm1Gla

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: B6.129-Atoh7tm1Gla

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: B6.129-Atoh7tm1Gla

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Resttm1.1Whk/Resttm1.1Whk,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7+,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Dmbx1tm3(cre)Aoh/Dmbx1tm3(cre)Aoh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Genetic Background: either: 129(Cg)-Atoh7tm1.1(Ascl1)Nlbr or B6.129S6(Cg)-Atoh7tm1.1(Ascl1)Nlbr or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: B6.129-Atoh7tm1Gla

 MP:0020548 decreased optic chiasm size "decreased size of the optic chiasm" [MGI:smb]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: B6.Cg-Atoh7tm1Gan

Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan,Pou4f2tm1Nat/Pou4f2tm1Nat
Genetic Background: B6.Cg-Pou4f2tm1Nat Atoh7tm1Gan

Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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