ENSMUSG00000048904


Mus musculus

Features
Gene ID: ENSMUSG00000048904
  
Biological name :Neurog1
  
Synonyms : Neurog1 / Neurogenin-1 / P70660
  
Possible biological names infered from orthology : Q92886
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56250478
Gene end: 56252163
  
Corresponding Affymetrix probe sets: 10409575 (MoGene1.0st)   1438551_at (Mouse Genome 430 2.0 Array)   1450836_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050484
NCBI entrez gene - 18014     See in Manteia.
MGI - MGI:107754
RefSeq - NM_010896
RefSeq Peptide - NP_035026
swissprot - P70660
Ensembl - ENSMUSG00000048904
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEUROG1ENSGALG00000029692Gallus gallus
 Q92886ENSG00000181965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431239
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796737
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825529
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801528
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798427
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470127
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304324
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762119
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681618
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227118


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032653  Neurogenin-1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007356 thorax and anterior abdomen determination IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021559 trigeminal nerve development IEA
 biological_processGO:0021650 vestibulocochlear nerve formation IEA
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0031223 auditory behavior IEA
 biological_processGO:0031536 positive regulation of exit from mitosis IMP
 biological_processGO:0035112 genitalia morphogenesis IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045664 regulation of neuron differentiation IGI
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048634 regulation of muscle organ development IEA
 biological_processGO:0048806 genitalia development IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0071626 mastication IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0097094 craniofacial suture morphogenesis IEA
 biological_processGO:0098583 learned vocalization behavior IEA
 biological_processGO:1901078 negative regulation of relaxation of muscle IEA
 biological_processGO:1905747 negative regulation of saliva secretion IEA
 biological_processGO:1905748 hard palate morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043204 perikaryon IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Neurog1tm1And/Neurog1tm1And,Neurog2tm3(Ascl1)Fgu/Neurog2tm3(Ascl1)Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001075 abnormal accessory nerve morphology "any malformation or misprojection of the 11th cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001097 abnormal superior glossopharyngeal ganglion morphology "malformation of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001101 abnormal superior vagus ganglion morphology "malformation of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0013183 absent trigeminal ganglion "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [MGI:anna]
Show

Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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