ENSMUSG00000044312


Mus musculus

Features
Gene ID: ENSMUSG00000044312
  
Biological name :Neurog3
  
Synonyms : Neurog3 / Neurogenin-3 / P70661
  
Possible biological names infered from orthology : Q9Y4Z2
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 62133090
Gene end: 62134763
  
Corresponding Affymetrix probe sets: 10363545 (MoGene1.0st)   1422312_a_at (Mouse Genome 430 2.0 Array)   1432034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151551
Ensembl peptide - ENSMUSP00000054054
NCBI entrez gene - 11925     See in Manteia.
MGI - MGI:893591
RefSeq - NM_009719
RefSeq Peptide - NP_033849
swissprot - A0A1W2P770
swissprot - P70661
swissprot - Q548G3
Ensembl - ENSMUSG00000044312
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurog3ENSDARG00000016951Danio rerio
 NEUROG3ENSGALG00000034810Gallus gallus
 Q9Y4Z2ENSG00000122859Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890444
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796738
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798429
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470127
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801527
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825527
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227121
8 / Atoh8 / Q99NA2 / Q96SQ7* / atonal bHLH transcription factor 8*ENSMUSG0000003762121
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304321
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681621


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032656  Neurogenin-3
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060290 transdifferentiation IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0003016 increased circulating bicarbonate level "elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005210 disorganized gastric mucosa "disorderly structure of the stomach epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005214 regional gastric metaplasia "localized areas of the stomach in which there is a change from one adult cell type to another adult cell type" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpatm4Nerl/Cebpatm4Nerl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005218 abnormal pancreatic delta cell morphology "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1(cre/ERT)Ggu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Neurog3tm1(cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu,Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0008141 decreased small intestinal microvillus size "reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Achetm4.1Pata/Achetm4.1Pata
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB * FVB/N

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0009173 absent pancreatic islets "absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009178 absent pancreatic alpha cells "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0010158 abnormal intestine development "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Neurog3tm1Fgu/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

Allelic Composition: Neurog3tm3Ggr/Neurog3tm3Ggr,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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