ENSMUSG00000037621


Mus musculus

Features
Gene ID: ENSMUSG00000037621
  
Biological name :Atoh8
  
Synonyms : 8 / Atoh8 / Q99NA2
  
Possible biological names infered from orthology : atonal bHLH transcription factor 8 / Q96SQ7
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 72206177
Gene end: 72235577
  
Corresponding Affymetrix probe sets: 10545372 (MoGene1.0st)   1426418_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145790
Ensembl peptide - ENSMUSP00000036981
NCBI entrez gene - 71093     See in Manteia.
MGI - MGI:1918343
RefSeq - NM_153778
RefSeq Peptide - NP_722473
swissprot - A0A0U1RP16
swissprot - Q99NA2
Ensembl - ENSMUSG00000037621
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atoh8ENSDARG00000037555Danio rerio
 ATOH8ENSGALG00000033083Gallus gallus
 ATOH8ENSG00000168874Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62414 / Neurod2 / neurogenic differentiation 2 / Q15784* / neuronal differentiation 2*ENSMUSG0000003825517
1 / Atoh1 / P48985 / Q92858* / atonal bHLH transcription factor 1*ENSMUSG0000007304316
Q60867 / Neurod1 / Neurogenic differentiation factor 1 / Q13562* / neuronal differentiation 1*ENSMUSG0000003470116
P48986 / Neurod6 / neurogenic differentiation 6 / Q96NK8* / neuronal differentiation 6*ENSMUSG0000003798415
Neurog2 / neurogenin 2 / Q9H2A3*ENSMUSG0000002796714
P70660 / Neurog1 / Neurogenin-1 / Q92886*ENSMUSG0000004890414
O09105 / Neurod4 / neurogenic differentiation 4 / Q9HD90* / neuronal differentiation 4*ENSMUSG0000004801514
P70661 / Neurog3 / Neurogenin-3 / Q9Y4Z2*ENSMUSG0000004431214
Q9QYC3 / Bhlha15 / Class A basic helix-loop-helix protein 15 / Q7RTS1* / basic helix-loop-helix family member a15*ENSMUSG0000005227113
7 / Atoh7 / Q9Z2E5 / Q8N100* / atonal bHLH transcription factor 7*ENSMUSG0000003681611


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032660  Protein atonal homologue 8
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001704 formation of primary germ layer IMP
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051450 myoblast proliferation IDA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Krt25M2Btlr/Krt25+
Genetic Background: C57BL/6J-Krt25M2Btlr

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tor1atm2Wtd/Tor1atm2Wtd
Genetic Background: involves: 129S1/Sv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr