ENSG00000168874


Homo sapiens

Features
Gene ID: ENSG00000168874
  
Biological name :ATOH8
  
Synonyms : ATOH8 / atonal bHLH transcription factor 8 / Q96SQ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p11.2
Gene start: 85751344
Gene end: 85788066
  
Corresponding Affymetrix probe sets: 1558705_at (Human Genome U133 Plus 2.0 Array)   1558706_a_at (Human Genome U133 Plus 2.0 Array)   228890_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304676
NCBI entrez gene - 84913     See in Manteia.
RefSeq - NM_032827
RefSeq Peptide - NP_116216
swissprot - Q96SQ7
Ensembl - ENSG00000168874
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atoh8ENSDARG00000037555Danio rerio
 ATOH8ENSGALG00000033083Gallus gallus
 8 ENSMUSG00000037621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15784 / NEUROD2 / neuronal differentiation 2ENSG0000017153218
ATOH1 / Q92858 / atonal bHLH transcription factor 1ENSG0000017223817
Q9H2A3 / NEUROG2 / neurogenin 2ENSG0000017840316
Q13562 / NEUROD1 / neuronal differentiation 1ENSG0000016299216
Q96NK8 / NEUROD6 / neuronal differentiation 6ENSG0000016460015
Q9Y4Z2 / NEUROG3 / neurogenin 3ENSG0000012285914
Q92886 / NEUROG1 / neurogenin 1ENSG0000018196514
Q9HD90 / NEUROD4 / neuronal differentiation 4ENSG0000012330714
Q7RTS1 / BHLHA15 / basic helix-loop-helix family member a15ENSG0000018053513
ATOH7 / Q8N100 / atonal bHLH transcription factor 7ENSG0000017977411


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032660  Protein atonal homologue 8
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001704 formation of primary germ layer IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035148 tube formation IMP
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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