ENSDARG00000056130


Danio rerio

Features
Gene ID: ENSDARG00000056130
  
Biological name :neurog1
  
Synonyms : neurog1 / neurogenin 1 / O42606
  
Possible biological names infered from orthology : NEUROG2 / neurogenin 2 / Q9H2A3
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 26703331
Gene end: 26704829
  
Corresponding Affymetrix probe sets: Dr.555.1.S1_at (Zebrafish Array)   NM_131041_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000073024
NCBI entrez gene - 30239     See in Manteia.
RefSeq - NM_131041
RefSeq Peptide - NP_571116
swissprot - O42606
ZFIN ID - ZDB-GENE-990415-174
Ensembl - ENSDARG00000056130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9H2A3ENSG00000178403Homo sapiens
 Neurog2ENSMUSG00000027967Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
neurog3 / neurogenin 3 / P70661* / Q9Y4Z2*ENSDARG0000001695133
Q6NYU3 / neurod6a / neuronal differentiation 6a / Q96NK8* / P48986* / NEUROD6* / neuronal differentiation 6* / neurogenic differentiation 6*ENSDARG0000004000828
neurod4 / neuronal differentiation 4 / O09105* / Q9HD90* / neurogenic differentiation 4*ENSDARG0000000346927
neurod2 / neurogenic differentiation 2 / Q15784* / Q62414* / neuronal differentiation 2*ENSDARG0000001685427
O42202 / neurod1 / neuronal differentiation 1 / Q13562* / Q60867* / Neurogenic differentiation factor 1 *ENSDARG0000001956627
Q9W6C7 / neurod6b / neuronal differentiation 6b / Q96NK8* / NEUROD6* / neuronal differentiation 6*ENSDARG0000002079425
atoh1a / atonal bHLH transcription factor 1a / 1 * / ATOH1* / P48985* / Q92858* / atonal bHLH transcription factor 1*ENSDARG0000005529424
bhlha15 / basic helix-loop-helix family, member a15 / Q7RTS1* / Q9QYC3* / Class A basic helix-loop-helix protein 15 *ENSDARG0000004516619
atoh7 / Q8AW52 / atonal bHLH transcription factor 7 / 7 * / Q8N100* / Q9Z2E5*ENSDARG0000006955218
atoh1c / atonal bHLH transcription factor 1cENSDARG0000003960218
atoh8 / D2CLZ9 / atonal bHLH transcription factor 8 / 8 * / Q96SQ7* / Q99NA2*ENSDARG0000003755515
BX957231.1ENSDARG000001147485


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032666  Basic helix-loop-helix neural transcription factor TAP-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0021575 hindbrain morphogenesis IGI
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021884 forebrain neuron development IMP
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0048909 anterior lateral line nerve development IMP
 biological_processGO:0048918 posterior lateral line nerve development IMP
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0071698 olfactory placode development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000048 olfactory placode olfactory placode pioneer neuron absent , abnormal
olfactory placode pioneer neuron decreased amount , abnormal
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 ZFA:0000051 otic vesicle otic vesicle neuron differentiation decreased process quality , abnormal
otic vesicle neuroblast (sensu Vertebrata) physical object quality , abnormal
otic vesicle neuroblast (sensu Vertebrata) poorly differentiated , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
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 ZFA:0000109 forebrain forebrain dopaminergic neuron absent , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve aplastic , abnormal
posterior lateral line nerve afferent neuron aplastic , abnormal
posterior lateral line nerve efferent neuron aplastic , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion morphology , abnormal
dorsal root ganglion decreased amount , abnormal
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 ZFA:0000243 neuromast neuromast mislocalised , abnormal
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 ZFA:0000267 primary olfactory fiber layer primary olfactory fiber layer morphology , abnormal
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 ZFA:0000281 hair cell posterior macula hair cell posterior macula increased amount , abnormal
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 ZFA:0000357 glomerular layer glomerular layer morphology , abnormal
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 ZFA:0000424 opercular lateral line opercular lateral line nerve absent , abnormal
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 ZFA:0000547 mouth mouth open , abnormal
mouth quality , abnormal
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 ZFA:0000558 posterior macula posterior macula increased size , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast quality , abnormal
posterior lateral line neuromast has fewer parts of type neuromast hair cell synaptic ribbon, abnormal
posterior lateral line neuromast innervation decreased occurrence , abnormal
posterior lateral line neuromast hair cell amount , ameliorated
posterior lateral line neuromast hair cell decreased amount , abnormal
posterior lateral line neuromast hair cell decreased amount , ameliorated
posterior lateral line neuromast hair cell decreased amount , exacerbated
posterior lateral line neuromast neuromast hair cell increased amount , abnormal
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 ZFA:0001094 whole organism whole organism movement behavioral quality , abnormal
whole organism shape , abnormal
whole organism bent , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion absent , abnormal
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 ZFA:0001481 ventral anterior lateral line nerve ventral anterior lateral line nerve decreased size , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
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 ZFA:0009238 afferent neuron afferent neuron neuron projection terminus decreased amount , abnormal
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 ZFA:0009242 primary neuron primary neuron decreased amount , abnormal
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 ZFA:0009366 hair cell hair cell decreased amount , abnormal
hair cell cytosol increased amount , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell synaptic ribbon increased amount , abnormal
neuromast hair cell synaptic ribbon mislocalised , abnormal
neuromast hair cell synaptic ribbon increased distance neuromast hair cell synaptic ribbon, abnormal
neuromast hair cell synaptic ribbon decreased size , abnormal
neuromast hair cell apoptotic process increased occurrence , abnormal
neuromast hair cell apoptotic process increased occurrence , exacerbated
neuromast hair cell apoptotic body increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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