ENSDARG00000019566


Danio rerio

Features
Gene ID: ENSDARG00000019566
  
Biological name :neurod1
  
Synonyms : neurod1 / neuronal differentiation 1 / O42202
  
Possible biological names infered from orthology : Neurogenic differentiation factor 1 / Q13562 / Q60867
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 44291721
Gene end: 44295071
  
Corresponding Affymetrix probe sets: Dr.556.1.S1_at (Zebrafish Array)   NM_130978_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000026490
NCBI entrez gene - 30169     See in Manteia.
RefSeq - NM_130978
RefSeq Peptide - NP_571053
swissprot - O42202
ZFIN ID - ZDB-GENE-990415-172
Ensembl - ENSDARG00000019566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEUROD1ENSGALG00000008908Gallus gallus
 Q13562ENSG00000162992Homo sapiens
 Q60867ENSMUSG00000034701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
neurod4 / neuronal differentiation 4 / O09105* / Q9HD90* / neurogenic differentiation 4*ENSDARG0000000346947
neurod2 / neurogenic differentiation 2 / Q15784* / Q62414* / neuronal differentiation 2*ENSDARG0000001685445
Q6NYU3 / neurod6a / neuronal differentiation 6a / Q96NK8* / P48986* / NEUROD6* / neuronal differentiation 6* / neurogenic differentiation 6*ENSDARG0000004000845
Q9W6C7 / neurod6b / neuronal differentiation 6b / Q96NK8* / NEUROD6* / neuronal differentiation 6*ENSDARG0000002079441
O42606 / neurog1 / neurogenin 1 / Q9H2A3* / NEUROG2* / neurogenin 2*ENSDARG0000005613016
atoh1a / atonal bHLH transcription factor 1a / 1 * / ATOH1* / P48985* / Q92858* / atonal bHLH transcription factor 1*ENSDARG0000005529414
neurog3 / neurogenin 3 / P70661* / Q9Y4Z2*ENSDARG0000001695114
atoh8 / D2CLZ9 / atonal bHLH transcription factor 8 / 8 * / Q96SQ7* / Q99NA2*ENSDARG0000003755513
bhlha15 / basic helix-loop-helix family, member a15 / Q7RTS1* / Q9QYC3* / Class A basic helix-loop-helix protein 15 *ENSDARG0000004516613
atoh7 / Q8AW52 / atonal bHLH transcription factor 7 / 7 * / Q8N100* / Q9Z2E5*ENSDARG0000006955213
atoh1c / atonal bHLH transcription factor 1cENSDARG0000003960211
BX957231.1ENSDARG000001147485


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR016637  Neurogenic differentiation factor NeuroD
 IPR022575  Neurogenic differentiation factor, domain of unknown function
 IPR032652  Neurogenic differentiation factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031099 regeneration IMP
 biological_processGO:0042051 compound eye photoreceptor development IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048923 posterior lateral line neuromast hair cell differentiation IMP
 biological_processGO:0060119 inner ear receptor cell development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer amount , ameliorated
retinal inner nuclear layer increased amount , abnormal
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 ZFA:0000152 retina retina Notch signaling pathway increased occurrence , abnormal
retina cell proliferation increased occurrence , abnormal
retina cell proliferation increased occurrence , ameliorated
retina cell proliferation increased occurrence , exacerbated
retina central region increased amount , abnormal
retina Notch signaling pathway decreased occurrence , abnormal
Show

 ZFA:0000243 neuromast neuromast shape , abnormal
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 ZFA:0000281 hair cell posterior macula hair cell posterior macula decreased amount , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001114 head head increased amount , abnormal
head decreased amount , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer amount , ameliorated
retinal outer nuclear layer increased amount , abnormal
retinal outer nuclear layer cell proliferation occurrence , ameliorated
retinal outer nuclear layer cell proliferation increased occurrence , abnormal
Show

 ZFA:0005147 regenerating tissue regenerating tissue cell proliferation increased occurrence , abnormal
regenerating tissue cell proliferation increased occurrence , ameliorated
regenerating tissue cell proliferation increased occurrence , exacerbated
regenerating tissue retinal inner nuclear layer increased amount , abnormal
regenerating tissue retinal outer nuclear layer increased amount , abnormal
regenerating tissue retinal cone cell amount , ameliorated
regenerating tissue retinal cone cell decreased amount , abnormal
regenerating tissue retinal rod cell amount , ameliorated
regenerating tissue retinal rod cell decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell absent , abnormal
retinal cone cell decreased amount , abnormal
retinal cone cell regeneration decreased occurrence , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell regeneration decreased occurrence , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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