ENSMUSG00000025207


Mus musculus

Features
Gene ID: ENSMUSG00000025207
  
Biological name :Sema4g
  
Synonyms : Q9WUH7 / Sema4g / Semaphorin-4G
  
Possible biological names infered from orthology : Q9NTN9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 44989101
Gene end: 45003397
  
Corresponding Affymetrix probe sets: 10463430 (MoGene1.0st)   1449202_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026225
Ensembl peptide - ENSMUSP00000137395
Ensembl peptide - ENSMUSP00000138321
NCBI entrez gene - 26456     See in Manteia.
MGI - MGI:1347047
RefSeq - NM_011976
RefSeq Peptide - NP_036106
swissprot - Q9WUH7
Ensembl - ENSMUSG00000025207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema4gaENSDARG00000076595Danio rerio
 sema4gbENSDARG00000088143Danio rerio
 SEMA4GENSGALG00000026957Gallus gallus
 Q9NTN9ENSG00000095539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64151 / Sema4c / Semaphorin-4C / Q9C0C4*ENSMUSG0000002612139
Q62179 / Sema4b / Semaphorin-4B ENSMUSG0000003053933
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145133
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062730
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888328
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025428
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806428
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190427
O88632 / Sema3f / Semaphorin-3F / Q13275*ENSMUSG0000003468427
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796927
P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E / O15041* / semaphorin 3E*ENSMUSG0000006353126
Q62181 / Sema3c / Semaphorin-3C / Q99985*ENSMUSG0000002878025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050919 negative chemotaxis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema4ctm1Matl/Sema4c+
Genetic Background: B6.129P2-Sema4ctm1Matl

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plxnb2tm1Matl/Plxnb2+,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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