ENSMUSG00000026121


Mus musculus

Features
Gene ID: ENSMUSG00000026121
  
Biological name :Sema4c
  
Synonyms : Q64151 / Sema4c / Semaphorin-4C
  
Possible biological names infered from orthology : Q9C0C4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 36548639
Gene end: 36558349
  
Corresponding Affymetrix probe sets: 10353899 (MoGene1.0st)   1433920_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142034
Ensembl peptide - ENSMUSP00000141833
Ensembl peptide - ENSMUSP00000142284
Ensembl peptide - ENSMUSP00000110643
Ensembl peptide - ENSMUSP00000141263
Ensembl peptide - ENSMUSP00000141527
NCBI entrez gene - 20353     See in Manteia.
MGI - MGI:109252
RefSeq - XM_017319410
RefSeq - XM_006495804
RefSeq - XM_006495805
RefSeq - XM_006495807
RefSeq - XM_006495808
RefSeq - XM_006495809
RefSeq - XM_006495810
RefSeq - NM_001126047
RefSeq - NM_001304329
RefSeq - NM_001304330
RefSeq - XM_006495803
RefSeq Peptide - NP_001291259
RefSeq Peptide - NP_001119519
RefSeq Peptide - NP_001291258
swissprot - A0A0A6YXK9
swissprot - Q64151
swissprot - A0A0A6YX48
Ensembl - ENSMUSG00000026121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema4cENSDARG00000079611Danio rerio
 Q9C0C4ENSG00000168758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WUH7 / Sema4g / Semaphorin-4G / Q9NTN9*ENSMUSG0000002520739
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145135
Q62179 / Sema4b / Semaphorin-4B ENSMUSG0000003053934
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806430
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062730
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888328
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796928
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025428
O88632 / Sema3f / Semaphorin-3F / Q13275*ENSMUSG0000003468426
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190426
P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E / O15041* / semaphorin 3E*ENSMUSG0000006353126
Q62181 / Sema3c / Semaphorin-3C / Q99985*ENSMUSG0000002878025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISS
 biological_processGO:0042692 muscle cell differentiation IMP
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Sema4ctm1Matl/Sema4c+
Genetic Background: B6.129P2-Sema4ctm1Matl

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

Allelic Composition: Plxnb2tm1Matl/Plxnb2+,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Sema4ctm1Matl/Sema4c+
Genetic Background: B6.129P2-Sema4ctm1Matl

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Sema4ctm1Matl/Sema4c+
Genetic Background: B6.129P2-Sema4ctm1Matl

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4g+
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4c+,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

Allelic Composition: Sema4ctm1Matl/Sema4ctm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Sema4ctm1Matl Sema4gtm1Kik

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htr1atm1Rhn/Htr1atm1Rhn
Genetic Background: involves: 129S/SvEv * 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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