ENSMUSG00000034684


Mus musculus

Features
Gene ID: ENSMUSG00000034684
  
Biological name :Sema3f
  
Synonyms : O88632 / Sema3f / Semaphorin-3F
  
Possible biological names infered from orthology : Q13275
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107681500
Gene end: 107710475
  
Corresponding Affymetrix probe sets: 10596747 (MoGene1.0st)   1420508_at (Mouse Genome 430 2.0 Array)   1425840_a_at (Mouse Genome 430 2.0 Array)   1438947_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141350
Ensembl peptide - ENSMUSP00000142221
Ensembl peptide - ENSMUSP00000142178
Ensembl peptide - ENSMUSP00000141878
Ensembl peptide - ENSMUSP00000141865
Ensembl peptide - ENSMUSP00000141668
Ensembl peptide - ENSMUSP00000079400
NCBI entrez gene - 20350     See in Manteia.
MGI - MGI:1096347
RefSeq - XM_017313229
RefSeq - XM_017313228
RefSeq - XM_017313227
RefSeq - XM_017313226
RefSeq - NM_001311151
RefSeq - XM_006511676
RefSeq - NM_011349
RefSeq Peptide - NP_001298080
RefSeq Peptide - NP_035479
swissprot - O88632
swissprot - A0A0A6YY06
swissprot - A0A0A6YW11
swissprot - A0A0A6YWS0
swissprot - A0A0A6YX80
swissprot - A0A0A6YXX2
Ensembl - ENSMUSG00000034684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema3faENSDARG00000011163Danio rerio
 sema3fbENSDARG00000055373Danio rerio
 SEMA3FENSGALG00000029621Gallus gallus
 Q13275ENSG00000001617Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62181 / Sema3c / Semaphorin-3C / Q99985*ENSMUSG0000002878051
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888346
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796944
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025444
P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E / O15041* / semaphorin 3E*ENSMUSG0000006353141
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190441
Q9WUH7 / Sema4g / Semaphorin-4G / Q9NTN9*ENSMUSG0000002520728
Q64151 / Sema4c / Semaphorin-4C / Q9C0C4*ENSMUSG0000002612128
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145128
Q62179 / Sema4b / Semaphorin-4B ENSMUSG0000003053927
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806425
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0021612 facial nerve structural organization IMP
 biological_processGO:0021637 trigeminal nerve structural organization IMP
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IMP
 biological_processGO:0036486 ventral trunk neural crest cell migration IMP
 biological_processGO:0040011 locomotion IC
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IGI
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0050919 negative chemotaxis IGI
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0097490 sympathetic neuron projection extension IMP
 biological_processGO:0097491 sympathetic neuron projection guidance IMP
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IMP
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0038191 neuropilin binding IBA
 molecular_functionGO:0045499 chemorepellent activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0000778 abnormal tract 
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.1Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.1Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Sema3ftm1Mom/Sema3f+,Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001064 absent trochlear nerve "missing nerve of the superior oblique muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.1Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0004082 abnormal habenula development "anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004106 lymphatic vessel hyperplasia "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.1Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.1Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009945 abnormal accessory olfactory bulb morphology "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp2tm1.2Mom/Nrp2tm1.2Mom,Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sema3ftm1Mom/Sema3f+,Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nrp2tm1.2Mom/Nrp2+,Sema3ftm1.2Ddg/Sema3f+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0010368 abnormal lymphatic system physiology "any functional anomaly of the interconnected system of spaces, organs and vessels between body tissues and organs through which fluid, fats, proteins, and lymphocytes are transported to the bloodstream as lymph, and microorganisms and other debris are removed from tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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