ENSMUSG00000063531


Mus musculus

Features
Gene ID: ENSMUSG00000063531
  
Biological name :Sema3e
  
Synonyms : P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
  
Possible biological names infered from orthology : O15041 / semaphorin 3E
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 14025276
Gene end: 14256689
  
Corresponding Affymetrix probe sets: 10519747 (MoGene1.0st)   1419717_at (Mouse Genome 430 2.0 Array)   1425906_a_at (Mouse Genome 430 2.0 Array)   1427673_a_at (Mouse Genome 430 2.0 Array)   1442226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073612
NCBI entrez gene - 20349     See in Manteia.
MGI - MGI:1340034
RefSeq - NM_011348
RefSeq Peptide - NP_035478
swissprot - P70275
Ensembl - ENSMUSG00000063531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema3eENSDARG00000036571Danio rerio
 SEMA3EENSGALG00000038225Gallus gallus
 O15041ENSG00000170381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190451
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888346
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025445
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796944
Q62181 / Sema3c / Semaphorin-3C / Q99985*ENSMUSG0000002878042
O88632 / Sema3f / Semaphorin-3F / Q13275*ENSMUSG0000003468442
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145129
Q62179 / Sema4b / Semaphorin-4B ENSMUSG0000003053929
Q9WUH7 / Sema4g / Semaphorin-4G / Q9NTN9*ENSMUSG0000002520728
Q64151 / Sema4c / Semaphorin-4C / Q9C0C4*ENSMUSG0000002612128
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062725
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015513  Semaphorin 3E
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030215 semaphorin receptor binding IPI
 molecular_functionGO:0038191 neuropilin binding IBA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1tm1Toc
Genetic Background: involves: 129/Sv

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1tm1Toc
Genetic Background: involves: 129/Sv

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plxnd1tm1Ddg/Plxnd1tm1Ddg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Plxnd1tm1Ddg/Plxnd1tm1Ddg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0012539 Bergmeister s papilla "a posterior remnant of the fetal hyaloid artery that arises from the center of the optic disc and consists of a small tuft of fibrous tissue" [MGI:anna]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030123 Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*  / complex / reaction






 

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