ENSMUSG00000028780


Mus musculus

Features
Gene ID: ENSMUSG00000028780
  
Biological name :Sema3c
  
Synonyms : Q62181 / Sema3c / Semaphorin-3C
  
Possible biological names infered from orthology : Q99985
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 17574281
Gene end: 17730268
  
Corresponding Affymetrix probe sets: 10519886 (MoGene1.0st)   1420696_at (Mouse Genome 430 2.0 Array)   1429348_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030568
Ensembl peptide - ENSMUSP00000132330
Ensembl peptide - ENSMUSP00000126614
NCBI entrez gene - 20348     See in Manteia.
MGI - MGI:107557
RefSeq - NM_013657
RefSeq Peptide - NP_038685
swissprot - E9Q0Z0
swissprot - E9PXL2
swissprot - Q62181
Ensembl - ENSMUSG00000028780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema3cENSDARG00000034300Danio rerio
 SEMA3CENSGALG00000040444Gallus gallus
 Q99985ENSG00000075223Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88632 / Sema3f / Semaphorin-3F / Q13275*ENSMUSG0000003468453
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888346
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025445
P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E / O15041* / semaphorin 3E*ENSMUSG0000006353144
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796943
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190443
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145129
Q9WUH7 / Sema4g / Semaphorin-4G / Q9NTN9*ENSMUSG0000002520728
Q64151 / Sema4c / Semaphorin-4C / Q9C0C4*ENSMUSG0000002612128
Q62179 / Sema4b / Semaphorin-4B ENSMUSG0000003053927
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806426
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001756 somitogenesis IEP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IEP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEP
 biological_processGO:0003350 pulmonary myocardium development IEP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0021915 neural tube development IEP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0060174 limb bud formation IEP
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IDA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:0140074 cardiac endothelial to mesenchymal transition IDA
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IPI
 molecular_functionGO:0038191 neuropilin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0006049 semilunar valve insufficiency "the semilunar valves do not close tightly enough to prevent leakage." [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0009389 abnormal extracutaneous pigmentation "any anomaly in the coloring of organs and tissues excluding the integument" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Sema3cL605P/Sema3cL605P
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0012729 abnormal common carotid artery morphology "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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