ENSMUSG00000030539


Mus musculus

Features
Gene ID: ENSMUSG00000030539
  
Biological name :Sema4b
  
Synonyms : Q62179 / Sema4b / Semaphorin-4B
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D2
Gene start: 80186841
Gene end: 80226527
  
Corresponding Affymetrix probe sets: 10554375 (MoGene1.0st)   1427586_at (Mouse Genome 430 2.0 Array)   1455678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032754
Ensembl peptide - ENSMUSP00000145622
NCBI entrez gene - 20352     See in Manteia.
MGI - MGI:107559
RefSeq - XM_011250830
RefSeq - NM_013659
RefSeq Peptide - NP_038687
swissprot - Q62179
Ensembl - ENSMUSG00000030539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema4baENSDARG00000074414Danio rerio
 sema4bbENSDARG00000076104Danio rerio
 SEMA4BENSGALG00000008297Gallus gallus
 SEMA4BENSG00000185033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64151 / Sema4c / Semaphorin-4C / Q9C0C4*ENSMUSG0000002612135
O09126 / Sema4d / Semaphorin-4D / Q92854*ENSMUSG0000002145134
Q9WUH7 / Sema4g / Semaphorin-4G / Q9NTN9*ENSMUSG0000002520734
Q62178 / Sema4a / Semaphorin-4A / Q9H3S1*ENSMUSG0000002806433
Q9Z123 / Sema4f / Semaphorin-4F / O95754* / ssemaphorin 4F*ENSMUSG0000000062732
Q4LFA9 / Sema3g / Semaphorin-3G / Q9NS98*ENSMUSG0000002190427
P70275 / Sema3e / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E / O15041* / semaphorin 3E*ENSMUSG0000006353127
Sema3b / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B / Q13214* / semaphorin 3B*ENSMUSG0000005796927
O08665 / Sema3a / Semaphorin-3A / Q14563*ENSMUSG0000002888326
Q8BH34 / Sema3d / Semaphorin-3D / O95025*ENSMUSG0000004025426
O88632 / Sema3f / Semaphorin-3F / Q13275*ENSMUSG0000003468426
Q62181 / Sema3c / Semaphorin-3C / Q99985*ENSMUSG0000002878025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050919 negative chemotaxis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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