ENSMUSG00000020323


Mus musculus
peptidaseactivityPrss57serineproteasestrypsinsfamilyextracellularserine-typedomainchymotrypsinpaclanhistidineactivesiteproteolysisregionspaceazurophilgranulelumenendopeptidaseheparinbindinghydrolase

Features
Gene ID: ENSMUSG00000020323
  
Biological name :Prss57
  
Synonyms : Prss57 / Q14B24 / Serine protease 57
  
Possible biological names infered from orthology : Q6UWY2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 79781474
Gene end: 79790961
  
Corresponding Affymetrix probe sets: 10370644 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000020573
Ensembl peptide - ENSMUSP00000130448
Ensembl peptide - ENSMUSP00000131642
Ensembl peptide - ENSMUSP00000132215
NCBI entrez gene - 73106     See in Manteia.
MGI - MGI:1920356
RefSeq - XM_011243584
RefSeq - XM_006514199
RefSeq - XM_006514200
RefSeq - XM_006514201
RefSeq - XM_006514202
RefSeq - NM_001042710
RefSeq Peptide - NP_001036175
swissprot - F7AUN8
swissprot - F6R4F9
swissprot - Q14B24
Ensembl - ENSMUSG00000020323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-21e2.13ENSDARG00000094840Danio rerio
 PRSS57ENSGALG00000035762Gallus gallus
 PRSS57ENSG00000185198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918637
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543735
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420634
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028433
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238533
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544332
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215632
Mcpt4 / mast cell protease 4ENSMUSG0000006106832
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178032
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544131
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222631
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222731
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031431
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925631
Cma2 / chymase 2, mast cellENSMUSG0000006828931
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136131
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215729
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313229
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222528


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processnitrogen compound metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic processorganic substance metabolic process
catalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting ocatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion bindingcarbohydrate derivative bindcarbohydrate derivative bindingsulfur compound bindingsulfur compound binding
extracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regionextracellular regioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0035578 azurophil granule lumen ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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