ENSMUSG00000022227


Mus musculus

Features
Gene ID: ENSMUSG00000022227
  
Biological name :Mcpt1
  
Synonyms : Mast cell protease 1 / Mcpt1 / P11034
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 56017971
Gene end: 56020384
  
Corresponding Affymetrix probe sets: 10415431 (MoGene1.0st)   1422352_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022836
NCBI entrez gene - 17224     See in Manteia.
MGI - MGI:96937
RefSeq - NM_008570
RefSeq Peptide - NP_032596
swissprot - P11034
swissprot - Q496V0
Ensembl - ENSMUSG00000022227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcpt4 / mast cell protease 4ENSMUSG0000006106878
Cma2 / chymase 2, mast cellENSMUSG0000006828969
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222668
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136168
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222552
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028448
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031447
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543746
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544146
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544346
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215646
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918646
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925645
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215744
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238538
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313237
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032336
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420636
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0035690 cellular response to drug IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Angptl4tm1Jig/Angptl4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Angptl4tm1Jig/Angptl4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Angptl4tm1Jig/Angptl4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Angptl4tm1Jig/Angptl4+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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