ENSMUSG00000061780


Mus musculus

Features
Gene ID: ENSMUSG00000061780
  
Biological name :Cfd
  
Synonyms : Cfd / Complement factor D / P03953
  
Possible biological names infered from orthology : P00746
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79890853
Gene end: 79892655
  
Corresponding Affymetrix probe sets: 10364542 (MoGene1.0st)   1417867_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056836
Ensembl peptide - ENSMUSP00000151894
NCBI entrez gene - 11537     See in Manteia.
MGI - MGI:87931
RefSeq - NM_001291915
RefSeq - NM_013459
RefSeq Peptide - NP_001278844
RefSeq Peptide - NP_038487
swissprot - Q3UP47
swissprot - P03953
swissprot - B7ZNS9
Ensembl - ENSMUSG00000061780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfdENSDARG00000039579Danio rerio
 CFDENSGALG00000040832Gallus gallus
 CFDENSG00000197766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032336
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238534
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313233
Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*ENSMUSG0000007918633
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544132
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544332
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420632
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543731
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222731
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028431
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031431
Mcpt4 / mast cell protease 4ENSMUSG0000006106831
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925630
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215629
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222529
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222629
Cma2 / chymase 2, mast cellENSMUSG0000006828929
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215728
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR037561  Complement factor D


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Alternative complement activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: P2rx7tm1Blo/P2rx7tm1Blo
Genetic Background: involves: 129 * C57BL/6

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sox2lcc/Sox2+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Cfdtm1Yxu/Cfdtm1Yxu
Genetic Background: B6.129P2-Cfdtm1Yxu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000090231 Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*  / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction






 

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