ENSMUSG00000079186


Mus musculus

Features
Gene ID: ENSMUSG00000079186
  
Biological name :Gzmc
  
Synonyms : Granzyme C / Gzmc / P08882
  
Possible biological names infered from orthology : granzyme B / GZMB / P10144
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 56231441
Gene end: 56234656
  
Corresponding Affymetrix probe sets: 10420302 (MoGene1.0st)   1421256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015585
NCBI entrez gene - 14940     See in Manteia.
MGI - MGI:109256
RefSeq - XM_011244963
RefSeq - NM_010371
RefSeq - XM_006518568
RefSeq Peptide - NP_034501
swissprot - Q0VB76
swissprot - P08882
Ensembl - ENSMUSG00000079186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gzm3ENSDARG00000078451Danio rerio
 gzm3.2ENSDARG00000055986Danio rerio
 gzm3.3ENSDARG00000093990Danio rerio
 gzm3.4ENSDARG00000076814Danio rerio
 ENSGALG00000044661Gallus gallus
 GZMBENSG00000100453Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gzmb / P04187 / granzyme B / P10144*ENSMUSG0000001543766
Gzmg / P13366 / granzyme G / GZMH* / P20718* / granzyme H*ENSMUSG0000004028461
Gzmf / P08883 / Granzyme F / GZMH* / P20718* / granzyme H*ENSMUSG0000001544160
Gzmd / P11033 / Granzyme D / GZMH* / P20718* / granzyme H*ENSMUSG0000005925659
Gzmn / granzyme N / GZMH* / P20718* / granzyme H*ENSMUSG0000001544358
Gzme / P08884 / Granzyme E / GZMH* / P20718* / granzyme H*ENSMUSG0000002215658
Ctsg / P28293 / cathepsin G / P08311*ENSMUSG0000004031452
Mcpt8 / P43430 / Mast cell protease 8 ENSMUSG0000002215748
Mcpt4 / mast cell protease 4ENSMUSG0000006106848
Mcpt9 / O35164 / Mast cell protease 9 ENSMUSG0000007136147
Mcpt1 / P11034 / Mast cell protease 1 ENSMUSG0000002222746
Cma2 / chymase 2, mast cellENSMUSG0000006828946
Mcpt2 / P15119 / mast cell protease 2ENSMUSG0000002222645
Cma1 / P21844 / Chymase / P23946* / chymase 1*ENSMUSG0000002222543
Prss57 / Q14B24 / Serine protease 57 / Q6UWY2*ENSMUSG0000002032342
Gzma / P11032 / Granzyme A / P12544*ENSMUSG0000002313239
Gzmm / granzyme M isoform 2 / P51124* / granzyme M*ENSMUSG0000005420638
Gzmk / O35205 / Granzyme K / P49863*ENSMUSG0000004238537
Cfd / P03953 / Complement factor D / P00746*ENSMUSG0000006178035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IBA
 biological_processGO:0019835 cytolysis IEA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction






 

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