ENSDARG00000116139


Danio rerio

Features
Gene ID: ENSDARG00000116139
  
Biological name :cdx1b
  
Synonyms : caudal type homeobox 1 b / cdx1b
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 43976075
Gene end: 43992027
  
Corresponding Affymetrix probe sets: Dr.22213.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000152903
NCBI entrez gene - 100004956     See in Manteia.
swissprot - A5PLE8
ZFIN ID - ZDB-GENE-070615-29
Ensembl - ENSDARG00000116139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdx4 / caudal type homeobox 4 / O14627* / Q07424* / Homeobox protein CDX-4 *ENSDARG0000003629247
cdx1a / caudal type homeobox 1a / CDX1* / P47902* / caudal type homeobox 1*ENSDARG0000011455446
Q9PWM3 / hoxc4a / homeobox C4a / HOXC4* / P09017* / Q08624* / homeobox C4*ENSDARG0000007033825
hoxb5b / homeobox B5bENSDARG0000005403023
P22574 / hoxb4a / homeobox B4a / HOXB4* / P10284* / P17483* / homeobox B4* / Homeobox protein Hox-B4 *ENSDARG0000001353323
hoxb5a / P09014 / homeobox B5aENSDARG0000001305723
hoxb7a / Q8AWY9 / homeobox B7aENSDARG0000005603022
Q9YGT6 / hoxa5a / homeobox A5a / HOXA5* / P09021* / P20719* / homeobox A5* / Homeobox protein Hox-A5 *ENSDARG0000010250122
hoxd4a / homeobox D4a / HOXD4* / P09016* / P10628* / homeobox D4* / Homeobox protein Hox-D4 *ENSDARG0000005927622
hoxb6a / homeobox B6aENSDARG0000001063021
hoxb6b / homeobox B6bENSDARG0000002651320
Q8AWZ0 / hoxb8a / homeobox B8a / HOXB8* / P09632* / P17481* / homeobox B8* / Homeobox protein Hox-B8 *ENSDARG0000005602720
hoxc6b / homeobox C6b / HOXC6* / P09630* / homeobox C6*ENSDARG0000010195420
Q68EH7 / hoxc8a / homeobox C8a / HOXC8* / P09025* / P31273* / homeobox C8* / Homeobox protein Hox-C8 *ENSDARG0000007034620
hoxb8b / Q8JH55 / homeobox B8bENSDARG0000005402518
hoxc5a / homeobox C5a / HOXC5* / Q00444* / P32043* / AC012531.3* / homeobox C5* / Homeobox protein Hox-C5 *ENSDARG0000007034018
hoxc6a / homeobox C6a / HOXC6* / P09630* / P10629* / homeobox C6* / Homeobox protein Hox-C6 *ENSDARG0000007034318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IBA
 biological_processGO:0009948 anterior/posterior axis specification IBA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0050673 epithelial cell proliferation IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased distance eye , abnormal
Show

 ZFA:0000112 gut gut decreased thickness , abnormal
Show

 ZFA:0000114 heart heart shape , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0000761 basal plate midbrain region basal plate midbrain region decreased size , abnormal
Show

 ZFA:0001076 intestinal bulb intestinal bulb morphology , abnormal
intestinal bulb microvillus decreased length , abnormal
intestinal bulb enterocyte decreased amount , abnormal
intestinal bulb microvillus decreased amount , abnormal
intestinal bulb cell proliferation increased process quality , abnormal
intestinal bulb enterocyte decreased height , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism increased curvature , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas decreased size , abnormal
Show

 ZFA:0001323 mid intestine mid intestine microvillus decreased length , abnormal
mid intestine goblet cell immature , abnormal
mid intestine microvillus decreased amount , abnormal
mid intestine cell proliferation increased process quality , abnormal
mid intestine enterocyte decreased height , abnormal
Show

 ZFA:0001338 intestine intestine decreased size , abnormal
intestine goblet cell decreased amount , abnormal
Show

 ZFA:0001344 zona limitans intrathalamica zona limitans intrathalamica decreased size , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium morphology , abnormal
intestinal epithelium goblet cell absent , abnormal
intestinal epithelium enterocyte absent , abnormal
Show

 ZFA:0005127 mid intestine epithelium mid intestine epithelium morphology , abnormal
mid intestine epithelium epithelial cell cuboid , abnormal
Show

 ZFA:0005128 posterior intestine epithelium posterior intestine epithelium epithelial cell cuboid , abnormal
Show

 ZFA:0009094 goblet cell goblet cell secretory granule decreased amount , abnormal
Show

 ZFA:0009097 enteroendocrine cell enteroendocrine cell absent , abnormal
enteroendocrine cell decreased amount , abnormal
Show

 ZFA:0009138 mesodermal cell mesodermal cell decreased amount , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell decreased amount , abnormal
Show

 ZFA:0009269 enterocyte enterocyte morphology , abnormal
enterocyte cuboid , abnormal
enterocyte microvillus decreased length , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell cuboid , abnormal
intestinal epithelial cell nucleus pleomorphic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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