ENSG00000121068


Homo sapiens

Features
Gene ID: ENSG00000121068
  
Biological name :TBX2
  
Synonyms : Q13207 / T-box 2 / TBX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.2
Gene start: 61399896
Gene end: 61409466
  
Corresponding Affymetrix probe sets: 205993_s_at (Human Genome U133 Plus 2.0 Array)   213417_at (Human Genome U133 Plus 2.0 Array)   221977_at (Human Genome U133 Plus 2.0 Array)   40560_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404781
Ensembl peptide - ENSP00000240328
NCBI entrez gene - 6909     See in Manteia.
OMIM - 600747
RefSeq - XM_011525159
RefSeq - NM_005994
RefSeq Peptide - NP_005985
swissprot - A0A024QZ86
swissprot - Q13207
swissprot - F8WCM9
Ensembl - ENSG00000121068
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx2aENSDARG00000018025Danio rerio
 tbx2bENSDARG00000006120Danio rerio
 TBX2ENSGALG00000034297Gallus gallus
 Tbx2ENSMUSG00000000093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBX3 / O15119 / T-box 3ENSG0000013511159
TBX5 / Q99593 / T-box 5ENSG0000008922523
TBX4 / P57082 / T-box 4ENSG0000012107523
TBX1 / O43435 / T-box 1ENSG0000018405823
TBX15 / Q96SF7 / T-box 15ENSG0000009260722
TBX18 / O95935 / T-box 18ENSG0000011283722
TBX10 / O75333 / T-box 10ENSG0000016780021
TBX6 / O95947 / T-box 6ENSG0000014992221
TBX20 / Q9UMR3 / T-box 20ENSG0000016453221
TBX22 / Q9Y458 / T-box 22ENSG0000012214520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR002070  Transcription factor, Brachyury
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR022582  Transcription factor, T-box, region of unknown function
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0003151 outflow tract morphogenesis ISS
 biological_processGO:0003203 endocardial cushion morphogenesis ISS
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007521 muscle cell fate determination ISS
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0008016 regulation of heart contraction ISS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0035050 embryonic heart tube development ISS
 biological_processGO:0035909 aorta morphogenesis ISS
 biological_processGO:0036302 atrioventricular canal development ISS
 biological_processGO:0042733 embryonic digit morphogenesis ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis ISS
 biological_processGO:0048738 cardiac muscle tissue development ISS
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation ISS
 biological_processGO:0060465 pharynx development ISS
 biological_processGO:0060560 developmental growth involved in morphogenesis IEA
 biological_processGO:0060596 mammary placode formation IEA
 biological_processGO:0090398 cellular senescence IDA
 biological_processGO:1901208 negative regulation of heart looping ISS
 biological_processGO:1901211 negative regulation of cardiac chamber formation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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