ENSDARG00000006120


Danio rerio

Features
Gene ID: ENSDARG00000006120
  
Biological name :tbx2b
  
Synonyms : Q7ZTU9 / T-box 2b / tbx2b
  
Possible biological names infered from orthology : Q13207 / Q60707 / T-box 2 / T-box transcription factor TBX2 / TBX2
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 27364394
Gene end: 27371340
  
Corresponding Affymetrix probe sets: Dr.8233.1.S1_at (Zebrafish Array)   NM_131051_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000107769
NCBI entrez gene - 30253     See in Manteia.
RefSeq - NM_131051
RefSeq Peptide - NP_571126
swissprot - Q7ZTU9
ZFIN ID - ZDB-GENE-990726-27
Ensembl - ENSDARG00000006120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX2ENSGALG00000034297Gallus gallus
 TBX2ENSG00000121068Homo sapiens
 Tbx2ENSMUSG00000000093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx2a / T-box 2a / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000001802578
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221657
tbx3b / T-box 3bENSDARG0000006150939
tbx5a / Q9IAK8 / T-box 5a / TBX5* / Q99593* / P70326* / T-box 5*ENSDARG0000002489423
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258222
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005822
tbx16 / T-box 16ENSDARG0000000732922
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515022
tbx1 / Q8AXX2 / T-box 1 / O43435*ENSDARG0000003189121
tbx6 / Q8JIS6 / T-box 6 / P70327* / O95947* / T-box transcription factor TBX6 *ENSDARG0000001178520
tbx18 / T-box 18 / O95935*ENSDARG0000003693020
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206019
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR002070  Transcription factor, Brachyury
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR022582  Transcription factor, T-box, region of unknown function


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003205 cardiac chamber development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0021538 epithalamus development IMP
 biological_processGO:0021982 pineal gland development IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0036302 atrioventricular canal development IGI
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0042461 photoreceptor cell development IMP
 biological_processGO:0043704 photoreceptor cell fate specification IMP
 biological_processGO:0046548 retinal rod cell development IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0046551 retinal cone cell fate commitment IMP
 biological_processGO:0048318 axial mesoderm development IDA
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IMP
 biological_processGO:0072019 proximal convoluted tubule development IMP
 biological_processGO:0072068 late distal convoluted tubule development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000019 epiphysis epiphysis decreased size , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000114 heart heart structure , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer disorganized , abnormal
Show

 ZFA:0000152 retina retina has fewer parts of type UV sensitive photoreceptor cell , abnormal
retina has extra parts of type retinal rod cell , abnormal
retina UV sensitive photoreceptor cell increased amount , abnormal
retina blue sensitive photoreceptor cell decreased amount , abnormal
Show

 ZFA:0000197 dorsal habenular nucleus dorsal habenular nucleus right side has extra parts of type neuron , abnormal
dorsal habenular nucleus lateral region has extra parts of type neuron , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
Show

 ZFA:0001200 corpuscles of Stannius corpuscles of Stannius increased distribution , abnormal
corpuscles of Stannius cell increased amount , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal decreased size , abnormal
Show

 ZFA:0001359 pineal complex pineal complex morphology , abnormal
pineal complex decreased amount , abnormal
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 ZFA:0001360 parapineal organ parapineal organ aplastic , abnormal
parapineal organ cell mislocalised , abnormal
parapineal organ has fewer parts of type cell , abnormal
parapineal organ cell decreased amount , abnormal
parapineal organ has fewer parts of type parapineal organ neuron, abnormal
parapineal organ neuron fate specification decreased occurrence , abnormal
parapineal organ has number of parapineal organ neuron, ameliorated
parapineal organ neuron fate specification occurrence , ameliorated
Show

 ZFA:0001617 otolith otolith fused with otolith , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule increased length , abnormal
pronephric proximal convoluted tubule increased distribution , abnormal
Show

 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule decreased length , abnormal
pronephric distal late tubule decreased distribution , abnormal
Show

 ZFA:0009221 UV sensitive photoreceptor cell UV sensitive photoreceptor cell morphology , abnormal
UV sensitive photoreceptor cell deformed , abnormal
UV sensitive photoreceptor cell has extra parts of type UV sensitive photoreceptor cell cone cell pedicle, abnormal
UV sensitive photoreceptor cell axon bifurcated , abnormal
UV sensitive photoreceptor cell decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell increased amount , abnormal
Show

 ZFA:0009315 horizontal cell horizontal cell synapse amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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