ENSDARG00000011785


Danio rerio

Features
Gene ID: ENSDARG00000011785
  
Biological name :tbx6
  
Synonyms : Q8JIS6 / T-box 6 / tbx6
  
Possible biological names infered from orthology : O95947 / P70327 / T-box transcription factor TBX6
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 3912544
Gene end: 3923070
  
Corresponding Affymetrix probe sets: Dr.18309.1.S1_at (Zebrafish Array)   NM_153666_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000015108
NCBI entrez gene - 192294     See in Manteia.
RefSeq - NM_153666
RefSeq Peptide - NP_705952
swissprot - Q8JIS6
ZFIN ID - ZDB-GENE-020416-5
Ensembl - ENSDARG00000011785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX6ENSG00000149922Homo sapiens
 Tbx6ENSMUSG00000030699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx16 / T-box 16ENSDARG0000000732917
tbx2b / Q7ZTU9 / T-box 2b / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000000612016
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221616
tbx3b / T-box 3bENSDARG0000006150915
tbx2a / T-box 2a / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000001802515
tbx5a / Q9IAK8 / T-box 5a / TBX5* / Q99593* / P70326* / T-box 5*ENSDARG0000002489414
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258214
tbx1 / Q8AXX2 / T-box 1 / O43435*ENSDARG0000003189114
tbx18 / T-box 18 / O95935*ENSDARG0000003693014
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515013
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005813
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206012
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0021523 somatic motor neuron differentiation IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048641 regulation of skeletal muscle tissue development IGI
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased amount , abnormal
Show

 ZFA:0000126 centrum centrum length , abnormal
Show

 ZFA:0000155 somite somite cell proliferation decreased process quality , abnormal
somite quality , abnormal
somite fused with somite , abnormal
somite lacks parts or has fewer parts of type fast muscle cell , abnormal
somite decreased distribution , abnormal
somite irregularly shaped , abnormal
somite disorganized , abnormal
somite deformed , abnormal
somite U-shaped , abnormal
somite adaxial cell decreased amount , abnormal
somite shape , abnormal
somite spatial pattern , ameliorated
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm decreased amount , abnormal
paraxial mesoderm amount , ameliorated
Show

 ZFA:0000519 hemal arch hemal arch irregular spatial pattern , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum absent , abnormal
Show

 ZFA:0001056 myotome myotome decreased size , abnormal
myotome shape , abnormal
myotome size , ameliorated
Show

 ZFA:0001066 neural arch neural arch irregular spatial pattern , abnormal
Show

 ZFA:0001080 sclerotome sclerotome spatial pattern , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001115 trunk trunk central region has fewer parts of type dermomyotome , abnormal
trunk central region has fewer parts of type dermomyotome , ameliorated
Show

 ZFA:0001117 post-vent region post-vent region quality , abnormal
post-vent region shape , abnormal
post-vent region decreased length , abnormal
Show

 ZFA:0001189 vertebra vertebra structure , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
Show

 ZFA:0001462 somite border somite border absent , abnormal
somite border aplastic , abnormal
somite border inconspicuous , abnormal
somite border irregular spatial pattern , abnormal
Show

 ZFA:0005179 MiP motor neuron MiP motor neuron axon irregular spatial pattern , abnormal
MiP motor neuron axon decreased length , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell mislocalised , abnormal
slow muscle cell mislocalised , ameliorated
Show

 ZFA:0009117 fast muscle cell fast muscle cell morphology , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon irregular spatial pattern , abnormal
CaP motoneuron axon increased amount , abnormal
CaP motoneuron axon decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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