ENSDARG00000007329


Danio rerio

Features
Gene ID: ENSDARG00000007329
  
Biological name :tbx16
  
Synonyms : T-box 16 / tbx16
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 51733907
Gene end: 51753604
  
Corresponding Affymetrix probe sets: Dr.179.1.S1_at (Zebrafish Array)   Dr.179.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000003051
swissprot - B8JL25
ZFIN ID - ZDB-GENE-990615-5
Ensembl - ENSDARG00000007329
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX6ENSGALG00000006374Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx2a / T-box 2a / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000001802533
tbx2b / Q7ZTU9 / T-box 2b / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000000612033
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221633
tbx6 / Q8JIS6 / T-box 6 / P70327* / O95947* / T-box transcription factor TBX6 *ENSDARG0000001178531
tbx3b / T-box 3bENSDARG0000006150927
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258227
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005827
tbx5a / Q9IAK8 / T-box 5a / TBX5* / Q99593* / P70326* / T-box 5*ENSDARG0000002489427
tbx1 / Q8AXX2 / T-box 1 / O43435*ENSDARG0000003189126
tbx18 / T-box 18 / O95935*ENSDARG0000003693026
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515025
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206025
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007498 mesoderm development IGI
 biological_processGO:0007525 somatic muscle development IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0031016 pancreas development IGI
 biological_processGO:0035775 pronephric glomerulus morphogenesis IMP
 biological_processGO:0039023 pronephric duct morphogenesis IMP
 biological_processGO:0042663 regulation of endodermal cell fate specification IGI
 biological_processGO:0048341 paraxial mesoderm formation IGI
 biological_processGO:0048389 intermediate mesoderm development IMP
 biological_processGO:0048565 digestive tract development IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0060809 mesodermal to mesenchymal transition involved in gastrulation IMP
 biological_processGO:0061053 somite development IGI
 biological_processGO:0061515 myeloid cell development IMP
 biological_processGO:0070121 Kupffer"s vesicle development IGI
 biological_processGO:0072045 convergent extension involved in nephron morphogenesis IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle physical object quality , abnormal
Kupffers vesicle decreased size , abnormal
Kupffers vesicle malformed , abnormal
Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle motile cilium decreased amount , abnormal
Kupffers vesicle ciliated cell absent , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta morphology , abnormal
Show

 ZFA:0000017 endoderm endoderm decreased amount , abnormal
endoderm spatial pattern , abnormal
Show

 ZFA:0000028 heart primordium heart primordium left side unfused from heart primordium right side, abnormal
Show

 ZFA:0000031 hypochord hypochord spatial pattern , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm absent , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000041 mesoderm mesoderm absent , abnormal
mesoderm morphology , abnormal
mesoderm decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord motor neuron increased amount , abnormal
spinal cord neuron increased amount , abnormal
spinal cord neuron disorganized , abnormal
spinal cord radial glial cell morphology , abnormal
Show

 ZFA:0000077 tail bud tail bud increased size , abnormal
tail bud increased distribution , abnormal
Show

 ZFA:0000084 yolk yolk condensed , abnormal
yolk teardrop-shaped , abnormal
Show

 ZFA:0000101 diencephalon diencephalon mislocalised , abnormal
Show

 ZFA:0000107 eye eye mislocalised , abnormal
eye fused with eye , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
gut malformed , abnormal
Show

 ZFA:0000114 heart heart decreased size , abnormal
heart quality , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment mislocalised , abnormal
Show

 ZFA:0000117 hypoblast hypoblast bleb increased amount , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm absent , abnormal
Show

 ZFA:0000123 liver liver spatial pattern , abnormal
liver position , abnormal
liver decreased amount , abnormal
liver hypoplastic , abnormal
liver quality , abnormal
liver absent , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
notochord kinked , abnormal
notochord morphology , abnormal
notochord quality , abnormal
notochord malformed , abnormal
Show

 ZFA:0000140 pancreas pancreas spatial pattern , abnormal
pancreas position , abnormal
pancreas decreased amount , abnormal
pancreas absent , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct proximal region decreased length , abnormal
pronephric duct distal region increased length , abnormal
Show

 ZFA:0000151 pronephros pronephros cell increased amount , abnormal
pronephros increased amount , abnormal
pronephros malformed , abnormal
pronephros aplastic , abnormal
Show

 ZFA:0000155 somite somite aplastic , abnormal
somite morphology , abnormal
somite quality , abnormal
somite decreased amount , abnormal
somite size , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm disorganized , abnormal
paraxial mesoderm decreased amount , abnormal
paraxial mesoderm morphology , abnormal
paraxial mesoderm absent , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000339 digestive system digestive system spatial pattern , abnormal
Show

 ZFA:0000416 presumptive endoderm presumptive endoderm decreased amount , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature posterior region absent , abnormal
Show

 ZFA:0000591 presumptive paraxial mesoderm presumptive paraxial mesoderm morphology , abnormal
Show

 ZFA:0001056 myotome myotome decreased amount , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold cell mislocalised , abnormal
Show

 ZFA:0001077 thymus primordium thymus primordium common lymphoid progenitor absent , abnormal
Show

 ZFA:0001094 whole organism whole organism posterior region has fewer parts of type muscle , abnormal
whole organism somite absent , abnormal
whole organism posterior region lacks all parts of type mesoderm , abnormal
whole organism lacks all parts of type pronephros , abnormal
whole organism posterior region morphology , abnormal
whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism wholly dorsalized , abnormal
Show

 ZFA:0001114 head head swollen , abnormal
head anterior-posterior axis decreased length , abnormal
head dorsal-ventral axis increased height , abnormal
Show

 ZFA:0001115 trunk trunk somite absent , abnormal
trunk somite decreased size , abnormal
trunk morphology , abnormal
trunk aplastic , abnormal
trunk anterior region decreased thickness , abnormal
trunk posterior region increased width , abnormal
trunk anterior region kinked , abnormal
trunk posterior region bulbous , abnormal
trunk somite aplastic , abnormal
trunk lacks all parts of type somite , abnormal
trunk muscle malformed , abnormal
trunk muscle disorganized , abnormal
Show

 ZFA:0001117 post-vent region post-vent region spade-shaped , abnormal
post-vent region somite decreased size , abnormal
post-vent region shape , abnormal
post-vent region aplastic , abnormal
post-vent region lacks all parts of type somite , abnormal
post-vent region quality , abnormal
post-vent region has extra parts of type somite , abnormal
post-vent region curved , abnormal
post-vent region increased size , abnormal
post-vent region somite absent , abnormal
Show

 ZFA:0001135 neural tube neural tube morphology , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin aplastic , abnormal
Show

 ZFA:0001206 intermediate mesoderm intermediate mesoderm spatial pattern , abnormal
Show

 ZFA:0001257 medial floor plate medial floor plate increased width , abnormal
medial floor plate cell mislocalised , abnormal
medial floor plate truncated , abnormal
medial floor plate posterior region absent , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel aplastic , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud split medially , abnormal
Show

 ZFA:0001462 somite border somite border morphology , abnormal
Show

 ZFA:0005023 hematopoietic system hematopoietic system absent , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell absent , abnormal
Show

 ZFA:0005249 vasculature vasculature spatial pattern , abnormal
Show

 ZFA:0009000 cell cell accumulation caudal fin , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009051 interneuron interneuron mislocalised medially , abnormal
interneuron decreased amount , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell decreased amount , abnormal
Show

 ZFA:0009138 mesodermal cell mesodermal cell spatial pattern , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell decreased amount , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron mislocalised , abnormal
primary motor neuron decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009258 angioblastic mesenchymal cell angioblastic mesenchymal cell spatial pattern , abnormal
Show

 ZFA:0009288 primordial germ cell primordial germ cell mislocalised , abnormal
Show

 ZFA:0009309 leukocyte leukocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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