ENSDARG00000031891


Danio rerio

Features
Gene ID: ENSDARG00000031891
  
Biological name :tbx1
  
Synonyms : Q8AXX2 / T-box 1 / tbx1
  
Possible biological names infered from orthology : O43435
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 15202495
Gene end: 15215483
  
Corresponding Affymetrix probe sets: Dr.19936.1.S1_at (Zebrafish Array)   NM_183339_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000118808
Ensembl peptide - ENSDARP00000040825
NCBI entrez gene - 368206     See in Manteia.
RefSeq - NM_183339
RefSeq Peptide - NP_899182
swissprot - B8JJ43
swissprot - Q8AXX2
ZFIN ID - ZDB-GENE-030805-5
Ensembl - ENSDARG00000031891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX1ENSGALG00000041182Gallus gallus
 TBX1ENSG00000184058Homo sapiens
 Tbx1ENSMUSG00000009097Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258232
tbx2b / Q7ZTU9 / T-box 2b / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000000612032
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515031
tbx2a / T-box 2a / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000001802531
tbx18 / T-box 18 / O95935*ENSDARG0000003693030
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221630
tbx5a / Q9IAK8 / T-box 5a / TBX5* / Q99593* / P70326* / T-box 5*ENSDARG0000002489430
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005830
tbx16 / T-box 16ENSDARG0000000732927
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206027
tbx3b / T-box 3bENSDARG0000006150926
tbx6 / Q8JIS6 / T-box 6 / P70327* / O95947* / T-box transcription factor TBX6 *ENSDARG0000001178526
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0042471 ear morphogenesis IMP
 biological_processGO:0043282 pharyngeal muscle development IMP
 biological_processGO:0043583 ear development IMP
 biological_processGO:0048538 thymus development ISS
 biological_processGO:0048703 embryonic viscerocranium morphogenesis ISS
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060017 parathyroid gland development ISS
 biological_processGO:0060023 soft palate development ISS
 biological_processGO:0060037 pharyngeal system development ISS
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0072513 positive regulation of secondary heart field cardioblast proliferation IMP
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043565 sequence-specific DNA binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle has fewer parts of type cardiac muscle cell , abnormal
cardiac ventricle increased width , abnormal
cardiac ventricle shortened , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000028 heart primordium heart primordium cell proliferation decreased process quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain neural crest cell decreased amount , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000056 pharynx pharynx malformed , abnormal
Show

 ZFA:0000076 swim bladder swim bladder non-functional , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton decreased size , abnormal
pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000114 heart heart straight , abnormal
heart decreased functionality , abnormal
heart decreased contractility , abnormal
heart symmetry , abnormal
Show

 ZFA:0000128 midbrain midbrain neural crest cell decreased amount , abnormal
midbrain quality , abnormal
midbrain morphology , abnormal
Show

 ZFA:0000135 notochord notochord mislocalised anteriorly , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus decreased length , abnormal
bulbus arteriosus immature , abnormal
bulbus arteriosus smooth muscle morphology , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear quality , abnormal
inner ear structure , abnormal
Show

 ZFA:0000225 lateral crista primordium lateral crista primordium aplastic , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000384 levator arcus palatini levator arcus palatini aplastic , abnormal
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 ZFA:0000386 macula macula decreased amount , abnormal
macula hypoplastic , abnormal
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 ZFA:0000393 mesenchyme mesenchyme decreased size , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000411 posterior crista primordium posterior crista primordium aplastic , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
semicircular canal hypoplastic , abnormal
Show

 ZFA:0000468 anterior crista primordium anterior crista primordium aplastic , abnormal
Show

 ZFA:0000471 atrium atrium decreased angle to cardiac ventricle , abnormal
atrium increased width , abnormal
atrium decreased size , abnormal
Show

 ZFA:0000498 dilator operculi dilator operculi aplastic , abnormal
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 ZFA:0000547 mouth mouth closure incomplete , abnormal
mouth mislocalised posteriorly , abnormal
mouth quality , abnormal
Show

 ZFA:0000608 ventral transverse ventral transverse aplastic , abnormal
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 ZFA:0001078 thymus thymus aplastic , abnormal
thymus hypoplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism circling , abnormal
whole organism movement behavioral quality , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch decreased amount , abnormal
pharyngeal pouch malformed , abnormal
pharyngeal pouch pharyngeal system development process quality , abnormal
pharyngeal pouch aplastic , abnormal
pharyngeal pouch absent , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage inverted , abnormal
Meckels cartilage mislocalised ventrally , abnormal
Meckels cartilage mislocalised posteriorly , abnormal
Meckels cartilage decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0001272 palatoquadrate arch palatoquadrate arch quality , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton decreased size , abnormal
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 ZFA:0001301 glossopharyngeal ganglion glossopharyngeal ganglion absent , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch muscle aplastic , abnormal
pharyngeal arch aplastic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage morphology , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage malformed , abnormal
parachordal cartilage mislocalised posteriorly , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
pharyngeal arch cartilage fused with pharyngeal arch cartilage , abnormal
pharyngeal arch cartilage disorganized , abnormal
pharyngeal arch cartilage decreased size , abnormal
Show

 ZFA:0001500 auditory capsule auditory capsule decreased size , abnormal
auditory capsule malformed , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
ceratobranchial cartilage decreased size , abnormal
ceratobranchial cartilage aplastic , abnormal
Show

 ZFA:0001555 epibranchial ganglion epibranchial ganglion increased size , abnormal
epibranchial ganglion fused with epibranchial ganglion , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 neural crest cell decreased amount , abnormal
pharyngeal arch 2 neural crest cell absent , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 neural crest cell decreased amount , abnormal
pharyngeal arch 1 neural crest cell present , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 neural crest cell fused with pharyngeal arch 3-7 neural crest cell, abnormal
pharyngeal arch 3-7 morphology , abnormal
pharyngeal arch 3-7 neural crest cell absent , abnormal
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 ZFA:0005004 aortic arch aortic arch decreased amount , abnormal
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 ZFA:0007050 constrictor dorsalis constrictor dorsalis morphology , abnormal
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 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell shape , abnormal
cardiac muscle cell circular , abnormal
cardiac muscle cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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