ENSDARG00000018025


Danio rerio

Features
Gene ID: ENSDARG00000018025
  
Biological name :tbx2a
  
Synonyms : T-box 2a / tbx2a
  
Possible biological names infered from orthology : Q13207 / Q60707 / T-box 2 / T-box transcription factor TBX2 / TBX2
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 56504717
Gene end: 56513825
  
Corresponding Affymetrix probe sets: Dr.22932.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000027905
NCBI entrez gene - 573084     See in Manteia.
swissprot - B0R122
ZFIN ID - ZDB-GENE-990917-4
Ensembl - ENSDARG00000018025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX2ENSGALG00000034297Gallus gallus
 TBX2ENSG00000121068Homo sapiens
 Tbx2ENSMUSG00000000093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx2b / Q7ZTU9 / T-box 2b / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000000612078
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221656
tbx3b / T-box 3bENSDARG0000006150938
tbx16 / T-box 16ENSDARG0000000732923
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005823
tbx5a / Q9IAK8 / T-box 5a / TBX5* / Q99593* / P70326* / T-box 5*ENSDARG0000002489423
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515022
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258221
tbx1 / Q8AXX2 / T-box 1 / O43435*ENSDARG0000003189121
tbx6 / Q8JIS6 / T-box 6 / P70327* / O95947* / T-box transcription factor TBX6 *ENSDARG0000001178520
tbx18 / T-box 18 / O95935*ENSDARG0000003693020
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206019
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR002070  Transcription factor, Brachyury
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR022582  Transcription factor, T-box, region of unknown function


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003205 cardiac chamber development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060037 pharyngeal system development IMP
 biological_processGO:0072019 proximal convoluted tubule development IMP
 biological_processGO:0072068 late distal convoluted tubule development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball increased size , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle cardiac muscle cell decreased amount , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000066 proctodeum proctodeum malformed , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
heart malformed , abnormal
Show

 ZFA:0000138 otic placode otic placode decreased size , abnormal
Show

 ZFA:0000151 pronephros pronephros posterior region decreased distribution , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0000360 heart tube heart tube position , abnormal
Show

 ZFA:0000471 atrium atrium increased size , abnormal
Show

 ZFA:0001094 whole organism whole organism axis curved , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch arrested , abnormal
Show

 ZFA:0001200 corpuscles of Stannius corpuscles of Stannius absent , abnormal
corpuscles of Stannius increased distribution , abnormal
corpuscles of Stannius cell increased amount , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch arrested , abnormal
pharyngeal arch malformed , abnormal
pharyngeal arch mesenchyme condensation cell fused with pharyngeal arch mesenchyme condensation cell, abnormal
pharyngeal arch disorganized , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal increased width , abnormal
atrioventricular canal aplastic , abnormal
Show

 ZFA:0001383 fin bud fin bud aplastic , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 malformed , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule increased length , abnormal
pronephric proximal convoluted tubule increased distribution , abnormal
Show

 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule decreased length , abnormal
pronephric distal late tubule decreased distribution , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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