ENSDARG00000024894


Danio rerio

Features
Gene ID: ENSDARG00000024894
  
Biological name :tbx5a
  
Synonyms : Q9IAK8 / T-box 5a / tbx5a
  
Possible biological names infered from orthology : P70326 / Q99593 / T-box 5 / TBX5
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 72264192
Gene end: 72289648
  
Corresponding Affymetrix probe sets: Dr.8077.1.S1_at (Zebrafish Array)   Dr.8077.2.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000033053
NCBI entrez gene - 30071     See in Manteia.
RefSeq - NM_001313682
RefSeq Peptide - NP_001300611
swissprot - Q9IAK8
ZFIN ID - ZDB-GENE-991124-7
Ensembl - ENSDARG00000024894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBX5ENSGALG00000008253Gallus gallus
 TBX5ENSG00000089225Homo sapiens
 Tbx5ENSMUSG00000018263Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbx4 / T-box 4 / P57082* / P70325*ENSDARG0000003005851
tbx5b / T-box 5b / TBX5* / P70326* / Q99593* / T-box 5*ENSDARG0000009206047
tbx2b / Q7ZTU9 / T-box 2b / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000000612032
tbx2a / T-box 2a / TBX2* / Q60707* / Q13207* / T-box 2* / T-box transcription factor TBX2 *ENSDARG0000001802532
tbx3a / T-box 3a / TBX3* / O15119* / P70324* / T-box 3*ENSDARG0000000221630
tbx15 / T-box 15 / O70306* / Q96SF7* / T-box transcription factor TBX15 *ENSDARG0000000258228
tbx1 / Q8AXX2 / T-box 1 / O43435*ENSDARG0000003189128
tbx3b / T-box 3bENSDARG0000006150927
tbx18 / T-box 18 / O95935*ENSDARG0000003693027
tbx20 / Q9I9K7 / T-box 20 / Q9UMR3* / Q9ES03* / T-box transcription factor TBX20 *ENSDARG0000000515027
tbx16 / T-box 16ENSDARG0000000732926
tbx6 / Q8JIS6 / T-box 6 / P70327* / O95947* / T-box transcription factor TBX6 *ENSDARG0000001178524
tbx22 / T-box 22 / Q8K402* / Q9Y458*ENSDARG0000009174821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0003190 atrioventricular valve formation IMP
 biological_processGO:0003294 atrial ventricular junction remodeling IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0003344 pericardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0021554 optic nerve development IGI
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0036302 atrioventricular canal development IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0060042 retina morphogenesis in camera-type eye IGI
 biological_processGO:0060174 limb bud formation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0015629 actin cytoskeleton IPI
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0032993 protein-DNA complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle amount , ameliorated
cardiac ventricle decreased contractility , abnormal
cardiac ventricle decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000108 fin fin agenesis , abnormal
fin morphology , abnormal
fin absent , abnormal
Show

 ZFA:0000114 heart heart structure , abnormal
heart morphology , abnormal
heart decreased size , abnormal
heart malformed , abnormal
heart edematous , abnormal
heart morphology , ameliorated
heart quality , abnormal
heart bifurcated , abnormal
heart physical object quality , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud absent , abnormal
pectoral fin bud aplastic , abnormal
Show

 ZFA:0000155 somite somite U-shaped , abnormal
somite shape , ameliorated
Show

 ZFA:0000360 heart tube heart tube bifurcated , abnormal
heart tube linear , abnormal
heart tube present , abnormal
heart tube myocardium decreased thickness , abnormal
heart tube shape , abnormal
Show

 ZFA:0000407 pectoral girdle pectoral girdle aplastic , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased thickness , abnormal
Show

 ZFA:0000471 atrium atrium amount , ameliorated
atrium decreased amount , abnormal
Show

 ZFA:0001000 mesenchyme pectoral fin mesenchyme pectoral fin flattened , abnormal
mesenchyme pectoral fin cell proliferation absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks parts or has fewer parts of type pectoral fin , abnormal
whole organism semi-lethal (sensu genetics) , abnormal
whole organism decreased amount , abnormal
whole organism amount , ameliorated
whole organism increased amount , abnormal
whole organism dead , abnormal
Show

 ZFA:0001115 trunk trunk curled , abnormal
trunk decreased length , abnormal
trunk bent , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin upturned , abnormal
pectoral fin absent , abnormal
pectoral fin aplastic , abnormal
pectoral fin hypoplastic , abnormal
pectoral fin truncated , abnormal
pectoral fin morphology , abnormal
pectoral fin morphology , ameliorated
pectoral fin quality , abnormal
pectoral fin decreased length , abnormal
pectoral fin curved dorsal , abnormal
pectoral fin physical object quality , abnormal
Show

 ZFA:0001307 pharyngeal musculature pharyngeal musculature morphology , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal morphology , abnormal
atrioventricular canal aplastic , abnormal
Show

 ZFA:0001319 myocardium myocardium disorganized , abnormal
myocardium myofibril disorganized , abnormal
Show

 ZFA:0001320 endocardium endocardium aplastic , abnormal
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 ZFA:0001551 pectoral fin lepidotrichium pectoral fin lepidotrichium decreased amount , abnormal
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 ZFA:0001719 presumptive cardiac ventricle heart tube presumptive cardiac ventricle heart tube decreased size , abnormal
Show

 ZFA:0005057 epicardium epicardium aplastic , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve structure , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
cardiac muscle cell mitochondrion increased amount , abnormal
cardiac muscle cell mitochondrion swollen , abnormal
cardiac muscle cell bicellular tight junction dissociated from cardiac muscle cell bicellular tight junction, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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