ENSMUSG00000035566


Mus musculus

Features
Gene ID: ENSMUSG00000035566
  
Biological name :Pcdh17
  
Synonyms : Pcdh17 / protocadherin 17
  
Possible biological names infered from orthology : O14917
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 84443563
Gene end: 84539002
  
Corresponding Affymetrix probe sets: 10416700 (MoGene1.0st)   1436920_at (Mouse Genome 430 2.0 Array)   1453070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071325
NCBI entrez gene - 219228     See in Manteia.
MGI - MGI:2684924
RefSeq - XM_017315983
RefSeq - NM_001013753
RefSeq - XM_006518905
RefSeq - XM_006518906
RefSeq Peptide - NP_001013775
swissprot - E9PXF0
Ensembl - ENSMUSG00000035566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcdh17ENSDARG00000027041Danio rerio
 PCDH17ENSGALG00000016941Gallus gallus
 O14917ENSG00000118946Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcdh19 / Q80TF3 / Protocadherin-19 / Q8TAB3*ENSMUSG0000005132347
Pcdh10 / protocadherin 10 / Q9P2E7*ENSMUSG0000004910035
Pcdh18 / Q8VHR0 / Protocadherin 18 / Q9HCL0*ENSMUSG0000003789234
Pcdh8 / Q7TSK3 / Protocadherin-8 / O95206*ENSMUSG0000003642229
Pcdhac2ENSMUSG0000010269729
O55134 / Pcdh12 / Protocadherin-12 / Q9NPG4*ENSMUSG0000002444029
Pcdhga10 / protocadherin gamma subfamily A, 10 / Q9Y5H3*ENSMUSG0000010222228
Q91XY4 / Pcdhga4 / Protocadherin gamma-A4 / Q9Y5G9* / protocadherin gamma subfamily A, 4*ENSMUSG0000010367728
Pcdhga7 / protocadherin gamma subfamily A, 7 / Q9Y5G6*ENSMUSG0000010347228
Pcdhga11 / protocadherin gamma subfamily A, 11 / Q9Y5H2*ENSMUSG0000010274227
Pcdhga5 / protocadherin gamma subfamily A, 5 / Q9Y5G8*ENSMUSG0000010356727
Pcdhga8 / protocadherin gamma subfamily A, 8 / Q9Y5G5*ENSMUSG0000010389727
Pcdhga3 / protocadherin gamma subfamily A, 3 / Q9Y5H0*ENSMUSG0000010434627
Pcdha2 / protocadherin alpha 2ENSMUSG0000010414826
Pcdha3 / protocadherin alpha 3ENSMUSG0000010231226
Pcdhga6 / protocadherin gamma subfamily A, 6 / Q9Y5G7*ENSMUSG0000010379326


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR013164  Cadherin, N-terminal
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR030709  Protocadherin-17


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0050805 negative regulation of synaptic transmission IMP
 biological_processGO:1904071 presynaptic active zone assembly IMP
 biological_processGO:2000807 regulation of synaptic vesicle clustering IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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