ENSMUSG00000000942


Mus musculus

Features
Gene ID: ENSMUSG00000000942
  
Biological name :Hoxa4
  
Synonyms : homeobox A4 / Hoxa4
  
Possible biological names infered from orthology : Q00056
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 52189671
Gene end: 52191753
  
Corresponding Affymetrix probe sets: 10544763 (MoGene1.0st)   1420226_x_at (Mouse Genome 430 2.0 Array)   1427354_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098943
NCBI entrez gene - 15401     See in Manteia.
MGI - MGI:96176
RefSeq - NM_008265
RefSeq Peptide - NP_032291
swissprot - A0A0R4J193
Ensembl - ENSMUSG00000000942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXA4ENSGALG00000022622Gallus gallus
 HOXA4ENSG00000197576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539446
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869246
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117443
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595643
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825330
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870028
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248527
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823627
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872126
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664825
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710225
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069025
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166125
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321924
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964621
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165721
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461920
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa4tm1Bhr/Hoxa4+
Genetic Background: 129S/SvEv-Hoxa4tm1Bhr

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa4tm1Bhr/Hoxa4+
Genetic Background: 129S/SvEv-Hoxa4tm1Bhr

Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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