ENSMUSG00000075394


Mus musculus

Features
Gene ID: ENSMUSG00000075394
  
Biological name :Hoxc4
  
Synonyms : homeobox C4 / Hoxc4 / Q08624
  
Possible biological names infered from orthology : P09017
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 103018934
Gene end: 103036852
  
Corresponding Affymetrix probe sets: 10427303 (MoGene1.0st)   1422870_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097740
Ensembl peptide - ENSMUSP00000133561
NCBI entrez gene - 15423     See in Manteia.
MGI - MGI:96195
RefSeq - XM_011245460
RefSeq - NM_013553
RefSeq - XM_006520461
RefSeq - XM_006520462
RefSeq - XM_006520463
RefSeq Peptide - NP_038581
swissprot - Q08624
swissprot - G3UX59
Ensembl - ENSMUSG00000075394
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc4aENSDARG00000070338Danio rerio
 HOXC4ENSGALG00000035539Gallus gallus
 HOXC4ENSG00000198353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117451
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595651
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869251
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094249
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825334
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870033
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823632
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248531
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069029
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166128
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872128
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710228
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321927
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165725
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664825
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461924
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964623
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048562 embryonic organ morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0071837 HMG box domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
Show

Allelic Composition: Fmn1ld-TgBri137/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmn1ld-TgBri137/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003159 abnormal esophageal smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004323 sternum hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004679 xiphoid process foramen "the appearance of a hole or holes in the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fmn1ld-TgBri137/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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