ENSMUSG00000027102


Mus musculus

Features
Gene ID: ENSMUSG00000027102
  
Biological name :Hoxd8
  
Synonyms : Homeobox protein Hox-D8 / Hoxd8 / P23463
  
Possible biological names infered from orthology : homeobox D8 / P13378
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 74704615
Gene end: 74707933
  
Corresponding Affymetrix probe sets: 10472965 (MoGene1.0st)   1431099_at (Mouse Genome 430 2.0 Array)   1433638_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019749
Ensembl peptide - ENSMUSP00000088094
Ensembl peptide - ENSMUSP00000118904
NCBI entrez gene - 15437     See in Manteia.
MGI - MGI:96209
RefSeq - NM_001290730
RefSeq - NM_001290731
RefSeq - NM_008276
RefSeq Peptide - NP_032302
RefSeq Peptide - NP_001277659
RefSeq Peptide - NP_001277660
swissprot - P23463
swissprot - F6W963
swissprot - A2ASN1
Ensembl - ENSMUSG00000027102
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXD8ENSGALG00000037272Gallus gallus
 HOXD8ENSG00000175879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664851
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165751
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823630
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825328
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069028
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872128
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117427
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595627
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539426
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870026
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321926
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248525
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166125
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094225
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869224
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132620
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964620
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048705 skeletal system morphogenesis IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxd8tm1Jdes/Hoxd8+
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Kmmt/Ptch1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Kmmt/Ptch1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Kmmt/Ptch1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxd8tm1Jdes/Hoxd8+
Genetic Background: involves: 129S2/SvPas * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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