ENSMUSG00000038253


Mus musculus

Features
Gene ID: ENSMUSG00000038253
  
Biological name :Hoxa5
  
Synonyms : Homeobox protein Hox-A5 / Hoxa5 / P09021
  
Possible biological names infered from orthology : homeobox A5 / P20719
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 52201754
Gene end: 52204587
  
Corresponding Affymetrix probe sets: 10544768 (MoGene1.0st)   1443803_x_at (Mouse Genome 430 2.0 Array)   1448926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039012
NCBI entrez gene - 15402     See in Manteia.
MGI - MGI:96177
RefSeq - NM_010453
RefSeq Peptide - NP_034583
swissprot - P09021
Ensembl - ENSMUSG00000038253
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxa5aENSDARG00000102501Danio rerio
 HOXA5ENSGALG00000025929Gallus gallus
 HOXA5ENSG00000106004Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870055
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248536
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117434
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595634
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539433
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869232
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823632
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069032
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094231
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872131
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321930
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710230
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664829
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166129
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165727
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132624
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964623
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IGI
 biological_processGO:0060435 bronchiole development IMP
 biological_processGO:0060439 trachea morphogenesis IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060480 lung goblet cell differentiation IMP
 biological_processGO:0060481 lobar bronchus epithelium development IMP
 biological_processGO:0060484 lung-associated mesenchyme development IMP
 biological_processGO:0060535 trachea cartilage morphogenesis IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0060574 intestinal epithelial cell maturation IMP
 biological_processGO:0060638 mesenchymal-epithelial cell signaling IMP
 biological_processGO:0060644 mammary gland epithelial cell differentiation IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0060764 cell-cell signaling involved in mammary gland development IMP
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000054 delayed ear emergence "late onset of the growth of the outer ear" [J:49421]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Kmt2atm3Mlc/Kmt2atm3Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0000501 abnormal digestive secretion "malfunction of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)444CLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna2d2du/Cacna2d2du
Genetic Background: TKDU/DnJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002249 abnormal larynx morphology "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002258 abnormal cricoid cartilage morphology "any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)444CLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003378 early sexual maturation "pubertal changes occur at an earlier than normal age" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003421 abnormal thyroid gland development "failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004551 decreased tracheal cartilage ring number "less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005629 abnormal lung weight "any change from the normal state in the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009018 short estrus "decrease in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009020 prolonged metestrus "increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0009438 fusion of cricoid and tracheal cartilages "union of the cricoid cartilage and one or more of the tracheal rings into one structure, when this fusion does not normally occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010861 increased respiratory mucosa goblet cell number "greater number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * MF1

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011028 impaired branching involved in bronchus morphogenesis 
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0011034 impaired branching involved in respiratory bronchiole morphogenesis 
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Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: 129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: 129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1Ljea/Hoxa5tm1Ljea
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0012668 absent sternal manubrium "absence of the cranial most segment of the sternum" [MGI:anna]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0013497 trachea occlusion "any impediment or blockage of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: 129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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