ENSMUSG00000001661


Mus musculus

Features
Gene ID: ENSMUSG00000001661
  
Biological name :Hoxc6
  
Synonyms : Homeobox protein Hox-C6 / Hoxc6 / P10629
  
Possible biological names infered from orthology : homeobox C6 / P09630
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102998257
Gene end: 103011881
  
Corresponding Affymetrix probe sets: 10427293 (MoGene1.0st)   1427361_at (Mouse Genome 430 2.0 Array)   1427362_x_at (Mouse Genome 430 2.0 Array)   1427454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001711
NCBI entrez gene - 15425     See in Manteia.
MGI - MGI:96197
RefSeq - XM_017316437
RefSeq - NM_010465
RefSeq - XM_006520468
RefSeq - XM_006520469
RefSeq Peptide - NP_034595
swissprot - B2RUB8
swissprot - P10629
Ensembl - ENSMUSG00000001661
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc6aENSDARG00000070343Danio rerio
 hoxc6bENSDARG00000101954Danio rerio
 HOXC6ENSGALG00000039051Gallus gallus
 HOXC6ENSG00000197757Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321937
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069036
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823635
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872134
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825333
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870032
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664832
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165732
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539431
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595631
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094231
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248531
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117431
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710231
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869230
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132623
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461923
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0048706 embryonic skeletal system development IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001881 abnormal mammary gland physiology "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004680 small xiphoid process "reduced size of the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa6tm1Mrc/Hoxa6tm1Mrc,Hoxb6tm1Mrc/Hoxb6tm1Mrc,Hoxc6tm1Dds/Hoxc6tm1Dds
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013711 abnormal inguinal mammary gland morphology "any structural anomaly of either of the two mammary glands located in the inguinal region between the hind legs (mice have a single pair of inguinal mammary glands)" [ISBN:1483269485, PMID:22949413]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013712 abnormal thoracic mammary gland morphology "any structural anomaly of any of the mammary glands located in the thoracic (i.e. pectoral or chest wall) region (mice have two pairs of thoracic mammary glands)" [ISBN:1483269485, PMID:22949413]
Show

Allelic Composition: Sept6tm1Nosa/Sept6tm1Nosa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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