ENSMUSG00000029646


Mus musculus

Features
Gene ID: ENSMUSG00000029646
  
Biological name :Cdx2
  
Synonyms : Cdx2 / Homeobox protein CDX-2 / P43241
  
Possible biological names infered from orthology : caudal type homeobox 2 / Q99626
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 147300805
Gene end: 147307270
  
Corresponding Affymetrix probe sets: 10535771 (MoGene1.0st)   1422074_at (Mouse Genome 430 2.0 Array)   1422075_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031650
NCBI entrez gene - 12591     See in Manteia.
MGI - MGI:88361
RefSeq - NM_007673
RefSeq Peptide - NP_031699
swissprot - P43241
swissprot - Q543L9
Ensembl - ENSMUSG00000029646
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDX2ENSGALG00000034983Gallus gallus
 CDX2ENSG00000165556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461942
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132635
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825320
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539420
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595619
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094219
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823619
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117419
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869219
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710218
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870018
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165717
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664817
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321917
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872116
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166116
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248516
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008333 endosome to lysosome transport IMP
 biological_processGO:0009887 animal organ morphogenesis IBA
 biological_processGO:0009948 anterior/posterior axis specification IBA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 biological_processGO:0060711 labyrinthine layer development IGI
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Ncstntm1.2Sud/Ncstntm1.2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0000487 absent intestinal cell "missing enterocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ncstntm1.2Sud/Ncstntm1.2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: B6.129X1-Cdx2tm1Mmt

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdx2tm1.1Lhn/Cdx2+,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Itgb1tm4Ref/Itgb1tm4Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3TgBR/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/H

 MP:0001711 abnormal placenta 
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Cdx4+
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdx2tm1.2Aral/Cdx2tm1Fbe
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0002043 colonic hamartoma "tumor-like focal abnormalities of the intestines; rarely neoplastic" [J:47050]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncstntm1.2Sud/Ncstntm1.2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx2tm1Yxz/Cdx2tm1Yxz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1.1Lhn/Cdx2+,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2+,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: B6.129X1-Cdx2tm1Mmt

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: B6.129X1-Cdx2tm1Mmt

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ

 MP:0004141 abnormal enteroendocrine cell morphology "malformation of the somatostatin and gastrin secreting epithelial cells present throughout the epithelium of the digestive tract" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004963 abnormal blastocoele morphology "any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: B6.129X1-Cdx2tm1Mmt

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdx2tm1Mmt/Cdx2+
Genetic Background: B6.129X1-Cdx2tm1Mmt

Allelic Composition: Cdx2tm1Mmt/Cdx2+,Apctm1Mmt/Apc+
Genetic Background: B6.129-Cdx2tm1Mmt Apctm1Mmt

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ

 MP:0008013 cecum polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the cecum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0008786 abnormal hindgut morphology "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Cdx4+
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3TgBR/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/H

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

Allelic Composition: Cdx2tm1.1Aral/Cdx2tm1Fbe,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx2tm1.2Aral/Cdx2tm1Fbe
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1.1Lhn/Cdx2tm1.1Lhn,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2tm1.1Lhn,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0011884 absent colon "absence of the portion of the large intestine between the cecum and the rectum" [MGI:Colin_McKerlie]
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Allelic Composition: Cdx2tm1Khk/Cdx2tm1Khk,Tg(Foxa3-cre)1Khk/0
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0012119 increased trophectoderm apoptosis "increase in the number of trophectoderm cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0012127 absent placenta hemotrichorial membrane "absence of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses" [MGI:anna]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2tm1.1Lhn,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2tm1.1Lhn,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0013168 absent hindlimb buds "absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2tm1.1Lhn,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0013487 abnormal Paneth cell physiology "any functional anomaly of the large secretory cells found at the base of the crypts of Lieberkuhn in the small intestine; Paneth cells contribute to the mucosal defense mechanism through the secretion of granules filled with antimicrobial (poly)peptides such as lysozyme, phospholipase A2, and defensins (called cryptdins in mice); Paneth cells secrete factors that help sustain and modulate the epithelial stem and progenitor cells that cohabitate in the crypts of Lieberkuhn and rejuvenate the small intestinal epithelium; dysfunction of Paneth cell biology contributes to the pathogenesis of chronic inflammatory bowel disease" [PMID:23398152]
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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