ENSMUSG00000115956


Mus musculus

Features
Gene ID: ENSMUSG00000115956
  
Biological name :Hoxd4
  
Synonyms : Homeobox protein Hox-D4 / Hoxd4 / P10628
  
Possible biological names infered from orthology : homeobox D4 / P09016
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 74721978
Gene end: 74729160
  
Corresponding Affymetrix probe sets: 10472970 (MoGene1.0st)   1450209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047949
NCBI entrez gene - 15436     See in Manteia.
MGI - MGI:96208
RefSeq - NM_010469
RefSeq Peptide - NP_034599
swissprot - P10628
Ensembl - ENSMUSG00000115956
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxd4aENSDARG00000059276Danio rerio
 HOXD4ENSGALG00000023419Gallus gallus
 HOXD4ENSG00000170166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG00000101174100
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539454
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869252
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094249
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825337
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248533
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870032
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069032
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823632
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872132
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710232
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321930
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166129
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664828
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165728
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461923
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964623
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048863 stem cell differentiation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxd4tm1Bhr/Hoxd4+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxd4tm1Bhr/Hoxd4+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxd4tm1Bhr/Hoxd4+
Genetic Background: involves: 129S/SvEv

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxd4tm1Bhr/Hoxd4+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004659 abnormal odontoid process "any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A02.835.232.834.151.383.668]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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