ENSG00000170166


Homo sapiens

Features
Gene ID: ENSG00000170166
  
Biological name :HOXD4
  
Synonyms : homeobox D4 / HOXD4 / P09016
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 176151222
Gene end: 176153226
  
Corresponding Affymetrix probe sets: 1552337_s_at (Human Genome U133 Plus 2.0 Array)   205522_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302548
NCBI entrez gene - 3233     See in Manteia.
OMIM - 142981
RefSeq - NM_014621
RefSeq Peptide - NP_055436
swissprot - P09016
Ensembl - ENSG00000170166
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxd4aENSDARG00000059276Danio rerio
 HOXD4ENSGALG00000023419Gallus gallus
 Hoxd4ENSMUSG00000115956Mus musculus
 Hoxd4ENSMUSG00000101174Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXC4 / P09017 / homeobox C4ENSG0000019835353
HOXA4 / Q00056 / homeobox A4ENSG0000019757652
HOXB4 / P17483 / homeobox B4ENSG0000018274251
HOXA5 / P20719 / homeobox A5ENSG0000010600436
HOXC5 / Q00444 / homeobox C5ENSG0000017278933
HOXB5 / P09067 / homeobox B5ENSG0000012007533
HOXB6 / P17509 / homeobox B6ENSG0000010851132
HOXA7 / P31268 / homeobox A7ENSG0000012259231
HOXB7 / P09629 / homeobox B7ENSG0000026002731
HOXD8 / P13378 / homeobox D8ENSG0000017587930
HOXB8 / P17481 / homeobox B8ENSG0000012006829
HOXA6 / P31267 / homeobox A6ENSG0000010600629
HOXC6 / P09630 / homeobox C6ENSG0000019775728
HOXC8 / P31273 / homeobox C8ENSG0000003796527
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372224
CDX2 / Q99626 / caudal type homeobox 2ENSG0000016555623
AC012531.3ENSG0000027304923
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126422


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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