ENSG00000198353


Homo sapiens

Features
Gene ID: ENSG00000198353
  
Biological name :HOXC4
  
Synonyms : homeobox C4 / HOXC4 / P09017
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 54016931
Gene end: 54056030
  
Corresponding Affymetrix probe sets: 206194_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399808
Ensembl peptide - ENSP00000305973
NCBI entrez gene - 3221     See in Manteia.
OMIM - 142974
RefSeq - NM_014620
RefSeq - NM_153633
RefSeq Peptide - NP_055435
RefSeq Peptide - NP_705897
swissprot - P09017
swissprot - A0A024RB51
Ensembl - ENSG00000198353
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc4aENSDARG00000070338Danio rerio
 HOXC4ENSGALG00000035539Gallus gallus
 Hoxc4ENSMUSG00000075394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXA4 / Q00056 / homeobox A4ENSG0000019757653
HOXD4 / P09016 / homeobox D4ENSG0000017016652
HOXB4 / P17483 / homeobox B4ENSG0000018274251
HOXA5 / P20719 / homeobox A5ENSG0000010600434
HOXB5 / P09067 / homeobox B5ENSG0000012007533
HOXA7 / P31268 / homeobox A7ENSG0000012259232
HOXC5 / Q00444 / homeobox C5ENSG0000017278930
HOXB6 / P17509 / homeobox B6ENSG0000010851129
HOXB7 / P09629 / homeobox B7ENSG0000026002728
HOXC6 / P09630 / homeobox C6ENSG0000019775728
HOXD8 / P13378 / homeobox D8ENSG0000017587928
HOXA6 / P31267 / homeobox A6ENSG0000010600627
HOXB8 / P17481 / homeobox B8ENSG0000012006825
HOXC8 / P31273 / homeobox C8ENSG0000003796525
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372223
CDX2 / Q99626 / caudal type homeobox 2ENSG0000016555623
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126421
AC012531.3ENSG0000027304920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048562 embryonic organ morphogenesis IEA
 biological_processGO:0051216 cartilage development IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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