ENSG00000182742


Homo sapiens

Features
Gene ID: ENSG00000182742
  
Biological name :HOXB4
  
Synonyms : homeobox B4 / HOXB4 / P17483
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48575513
Gene end: 48580111
  
Corresponding Affymetrix probe sets: 231767_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328928
NCBI entrez gene - 3214     See in Manteia.
OMIM - 142965
RefSeq - NM_024015
RefSeq Peptide - NP_076920
swissprot - P17483
Ensembl - ENSG00000182742
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb4aENSDARG00000013533Danio rerio
 HOXB4ENSGALG00000000284Gallus gallus
 Hoxb4ENSMUSG00000038692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXA4 / Q00056 / homeobox A4ENSG0000019757659
HOXC4 / P09017 / homeobox C4ENSG0000019835354
HOXD4 / P09016 / homeobox D4ENSG0000017016652
HOXA5 / P20719 / homeobox A5ENSG0000010600434
HOXB5 / P09067 / homeobox B5ENSG0000012007533
HOXB6 / P17509 / homeobox B6ENSG0000010851132
HOXB7 / P09629 / homeobox B7ENSG0000026002731
HOXC5 / Q00444 / homeobox C5ENSG0000017278930
HOXD8 / P13378 / homeobox D8ENSG0000017587930
HOXA7 / P31268 / homeobox A7ENSG0000012259229
HOXA6 / P31267 / homeobox A6ENSG0000010600629
HOXC6 / P09630 / homeobox C6ENSG0000019775728
HOXB8 / P17481 / homeobox B8ENSG0000012006825
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372225
HOXC8 / P31273 / homeobox C8ENSG0000003796525
CDX2 / Q99626 / caudal type homeobox 2ENSG0000016555624
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126422
AC012531.3ENSG0000027304922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002011 morphogenesis of an epithelial sheet IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048539 bone marrow development IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IDA
 biological_processGO:2000738 positive regulation of stem cell differentiation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005813 centrosome IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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