ENSMUSG00000038692


Mus musculus

Features
Gene ID: ENSMUSG00000038692
  
Biological name :Hoxb4
  
Synonyms : Homeobox protein Hox-B4 / Hoxb4 / P10284
  
Possible biological names infered from orthology : homeobox B4 / P17483
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96318267
Gene end: 96321638
  
Corresponding Affymetrix probe sets: 10380648 (MoGene1.0st)   1451761_at (Mouse Genome 430 2.0 Array)   1460379_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048002
NCBI entrez gene - 15412     See in Manteia.
MGI - MGI:96185
RefSeq - NM_010459
RefSeq Peptide - NP_034589
swissprot - P10284
Ensembl - ENSMUSG00000038692
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb4aENSDARG00000013533Danio rerio
 HOXB4ENSGALG00000000284Gallus gallus
 HOXB4ENSG00000182742Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539454
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094252
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117452
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595652
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825334
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870032
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069032
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872130
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248530
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823629
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166128
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710228
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321928
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461926
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165726
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664825
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132623
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002011 morphogenesis of an epithelial sheet IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048103 somatic stem cell division IDA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048539 bone marrow development IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0060216 definitive hemopoiesis IGI
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:2000738 positive regulation of stem cell differentiation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb2tm1Mrc/Hoxb2+,Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hoxb4tm1.1Mev/Hoxb4tm1.1Mev
Genetic Background: involves: 129/Sv

Allelic Composition: Hoxb3tm1.1Karl/Hoxb3tm1.1Karl,Hoxb4tm2.1Karl/Hoxb4tm2.1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb4tm2.1Nrm/Hoxb4tm2.1Nrm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Hoxb4tm2Nrm/Hoxb4tm2Nrm
Genetic Background: involves: 129 * C57BL/6

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb4tm2Nrm/Hoxb4tm2Nrm
Genetic Background: involves: 129 * C57BL/6

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003388 absent pericardium "absence of the fibroserous membrane covering the heart and beginning of the great vessels" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: 129S/SvEv-Hoxb4tm1Bay

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb4tm2Nrm/Hoxb4tm2Nrm
Genetic Background: involves: 129 * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: 129S/SvEv-Hoxb4tm1Bay

Allelic Composition: Hoxb2tm1Mrc/Hoxb2+,Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm2Bay/Hoxb4tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: 129S/SvEv-Hoxb4tm1Bay

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb4tm2Bay/Hoxb4tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: 129S/SvEv-Hoxb4tm1Bay

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Hoxb2tm1Mrc/Hoxb2+,Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxa4tm1Bhr/Hoxa4tm1Bhr,Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay,Hoxd4tm1Bhr/Hoxd4tm1Bhr
Genetic Background: involves: 129S/SvEv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxb4tm1Bay/Hoxb4tm1Bay
Genetic Background: 129S/SvEv-Hoxb4tm1Bay

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb2tm1Mrc/Hoxb2+,Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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