ENSMUSG00000038700


Mus musculus

Features
Gene ID: ENSMUSG00000038700
  
Biological name :Hoxb5
  
Synonyms : Homeobox protein Hox-B5 / Hoxb5 / P09079
  
Possible biological names infered from orthology : homeobox B5 / P09067
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96303336
Gene end: 96306121
  
Corresponding Affymetrix probe sets: 10380641 (MoGene1.0st)   1418415_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035423
NCBI entrez gene - 15413     See in Manteia.
MGI - MGI:96186
RefSeq - NM_008268
RefSeq Peptide - NP_032294
swissprot - P09079
Ensembl - ENSMUSG00000038700
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXB5ENSG00000120075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825355
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248536
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823635
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872132
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321932
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069032
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539432
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094230
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117430
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595630
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869229
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710228
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664828
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165728
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166128
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132625
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461923
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045446 endothelial cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IGI
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna2d2du/Cacna2d2du
Genetic Background: TKDU/DnJ

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb5tm1Mrc/Hoxb5+,Hoxb6tm1Mrc/Hoxb6+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxb5tm1Mrc/Hoxb5+,Hoxb6tm1Mrc/Hoxb6+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0012668 absent sternal manubrium "absence of the cranial most segment of the sternum" [MGI:anna]
Show

Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Hoxb5tm1Mrc/Hoxb5tm1Mrc,Hoxc5tm1Mrc/Hoxc5tm1Mrc
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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