ENSMUSG00000031326


Mus musculus

Features
Gene ID: ENSMUSG00000031326
  
Biological name :Cdx4
  
Synonyms : Cdx4 / Homeobox protein CDX-4 / Q07424
  
Possible biological names infered from orthology : caudal type homeobox 4 / O14627
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 103321398
Gene end: 103330592
  
Corresponding Affymetrix probe sets: 10601298 (MoGene1.0st)   1421552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033689
NCBI entrez gene - 12592     See in Manteia.
MGI - MGI:88362
RefSeq - NM_007674
RefSeq Peptide - NP_031700
swissprot - Q07424
swissprot - Q78Z64
Ensembl - ENSMUSG00000031326
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdx4ENSDARG00000036292Danio rerio
 ENSGALG00000007656Gallus gallus
 CDX4ENSGALG00000007657Gallus gallus
 CDX4ENSG00000131264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461939
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964639
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870024
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825323
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710221
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539421
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094221
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869220
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117420
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248520
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595620
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321920
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823620
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166119
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872119
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069019
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664819
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IBA
 biological_processGO:0009948 anterior/posterior axis specification IBA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060711 labyrinthine layer development IGI
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Cdx4+
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv

Allelic Composition: Cdx4tm1.1Gqda/Cdx4tm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmpktm1Rdd/Dmpk+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Cdx4+
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0012127 absent placenta hemotrichorial membrane "absence of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses" [MGI:anna]
Show

Allelic Composition: Cdx2tm1Fbe/Cdx2+,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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