ENSG00000175879


Homo sapiens

Features
Gene ID: ENSG00000175879
  
Biological name :HOXD8
  
Synonyms : homeobox D8 / HOXD8 / P13378
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 176129694
Gene end: 176132695
  
Corresponding Affymetrix probe sets: 231906_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406045
Ensembl peptide - ENSP00000437431
Ensembl peptide - ENSP00000409026
Ensembl peptide - ENSP00000315949
NCBI entrez gene - 3234     See in Manteia.
OMIM - 142985
RefSeq - NM_001199746
RefSeq - NM_001199747
RefSeq - NM_019558
RefSeq Peptide - NP_001186676
RefSeq Peptide - NP_062458
RefSeq Peptide - NP_001186675
swissprot - P13378
swissprot - A0A0A0MSX5
swissprot - A0A0A0MTF4
Ensembl - ENSG00000175879
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXD8ENSGALG00000037272Gallus gallus
 Hoxd8ENSMUSG00000027102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXC8 / P31273 / homeobox C8ENSG0000003796552
HOXB8 / P17481 / homeobox B8ENSG0000012006851
HOXA7 / P31268 / homeobox A7ENSG0000012259231
HOXB6 / P17509 / homeobox B6ENSG0000010851129
HOXA5 / P20719 / homeobox A5ENSG0000010600428
HOXB7 / P09629 / homeobox B7ENSG0000026002728
HOXD4 / P09016 / homeobox D4ENSG0000017016627
HOXA6 / P31267 / homeobox A6ENSG0000010600627
HOXB5 / P09067 / homeobox B5ENSG0000012007526
HOXB4 / P17483 / homeobox B4ENSG0000018274226
HOXC4 / P09017 / homeobox C4ENSG0000019835326
HOXA4 / Q00056 / homeobox A4ENSG0000019757626
HOXC6 / P09630 / homeobox C6ENSG0000019775726
HOXC5 / Q00444 / homeobox C5ENSG0000017278924
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126420
CDX2 / Q99626 / caudal type homeobox 2ENSG0000016555620
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372219
AC012531.3ENSG0000027304917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008595 anterior/posterior axis specification, embryo NAS
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 cellular_componentGO:0005634 nucleus NAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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