ENSG00000165556


Homo sapiens

Features
Gene ID: ENSG00000165556
  
Biological name :CDX2
  
Synonyms : caudal type homeobox 2 / CDX2 / Q99626
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.2
Gene start: 27962137
Gene end: 27971139
  
Corresponding Affymetrix probe sets: 206387_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370408
NCBI entrez gene - 1045     See in Manteia.
OMIM - 600297
RefSeq - XM_011534877
RefSeq - NM_001265
RefSeq - XM_011534875
RefSeq - XM_011534876
RefSeq Peptide - NP_001256
swissprot - Q99626
Ensembl - ENSG00000165556
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDX2ENSGALG00000034983Gallus gallus
 Cdx2ENSMUSG00000029646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372242
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126436
HOXA4 / Q00056 / homeobox A4ENSG0000019757621
HOXA5 / P20719 / homeobox A5ENSG0000010600420
HOXC4 / P09017 / homeobox C4ENSG0000019835320
HOXD4 / P09016 / homeobox D4ENSG0000017016619
HOXA7 / P31268 / homeobox A7ENSG0000012259219
HOXD8 / P13378 / homeobox D8ENSG0000017587919
HOXB4 / P17483 / homeobox B4ENSG0000018274219
HOXB5 / P09067 / homeobox B5ENSG0000012007519
HOXC8 / P31273 / homeobox C8ENSG0000003796518
HOXB8 / P17481 / homeobox B8ENSG0000012006818
HOXB7 / P09629 / homeobox B7ENSG0000026002718
HOXA6 / P31267 / homeobox A6ENSG0000010600617
HOXC5 / Q00444 / homeobox C5ENSG0000017278917
HOXB6 / P17509 / homeobox B6ENSG0000010851116
HOXC6 / P09630 / homeobox C6ENSG0000019775716
AC012531.3ENSG0000027304912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0009948 anterior/posterior axis specification IBA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0014807 regulation of somitogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060575 intestinal epithelial cell differentiation IEA
 biological_processGO:0060711 labyrinthine layer development IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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