ENSDARG00000055291


Danio rerio

Features
Gene ID: ENSDARG00000055291
  
Biological name :rab18a
  
Synonyms : rab18a / RAB18A, member RAS oncogene family
  
Possible biological names infered from orthology : P35293 / Q9NP72 / RAB18 / RAB18, member RAS oncogene family
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 22921477
Gene end: 22933524
  
Corresponding Affymetrix probe sets: Dr.5298.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072097
Ensembl peptide - ENSDARP00000124063
NCBI entrez gene - 325255     See in Manteia.
RefSeq - NM_206830
RefSeq Peptide - NP_996661
swissprot - F8W3J3
swissprot - Q6P129
ZFIN ID - ZDB-GENE-030131-3980
Ensembl - ENSDARG00000055291
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB18ENSGALG00000007435Gallus gallus
 RAB18ENSG00000099246Homo sapiens
 Rab18ENSMUSG00000073639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6DHC1 / rab18b / RAB18B, member RAS oncogene family / RAB18* / Q9NP72* / P35293* / RAB18, member RAS oncogene family*ENSDARG0000009834484
rab2a / RAB2A, member RAS oncogene family / P53994* / P61019* / Ras-related protein Rab-2A *ENSDARG0000002026142
rab11bb / RAB11B, member RAS oncogene family, b / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*ENSDARG0000009008640
rab14l / RAB14, member RAS oncogene family, likeENSDARG0000003518840
rab14 / RAB14, member RAS oncogene family / P61106* / Q91V41*ENSDARG0000007424640
rab11al / RAB11a, member RAS oncogene family, likeENSDARG0000001434039
rab25b / RAB25, member RAS oncogene family b / RAB25* / P57735* / RAB25, member RAS oncogene family*ENSDARG0000005295439
rab11ba / RAB11B, member RAS oncogene family, a / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*ENSDARG0000004187839
rab4b / RAB4B, member RAS oncogene family / Q91ZR1* / P61018* / RAB4B-EGLN2* / RAB4B-EGLN2 readthrough (NMD candidate)*ENSDARG0000001217738
rab11a / RAB11a, member RAS oncogene familyENSDARG0000004145038
rab25a / RAB25, member RAS oncogene family a / RAB25* / Q9WTL2* / P57735* / RAB25, member RAS oncogene family*ENSDARG0000005880038
rab4a / Q6PHI9 / RAB4a, member RAS oncogene family / P56371* / P20338* / Ras-related protein Rab-4A *ENSDARG0000001914437
CU571310.1 / RAB42* / Q8N4Z0* / RAB42, member RAS oncogene family*ENSDARG0000010258035
rab42a / RAB42, member RAS oncogene family aENSDARG0000003421535
rab42b / RAB42, member RAS oncogene familyENSDARG0000010117035
rab39ba / RAB39B, member RAS oncogene family a / RAB39B* / Q8BHC1* / Q96DA2* / RAB39B, member RAS oncogene family*ENSDARG0000001931233
rab39bb / RAB39B, member RAS oncogene family b / RAB39B* / Q8BHC1* / Q96DA2* / RAB39B, member RAS oncogene family*ENSDARG0000003650133
si:dkey-34d22.2ENSDARG0000010037930
si:dkey-34d22.5ENSDARG0000010486528
si:ch211-247i17.1ENSDARG0000007672720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR025662  Sigma-54 interaction domain, ATP-binding site 1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0034389 lipid particle organization IBA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0005794 Golgi apparatus IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton immature , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044136 rab3gap2 / RAB3 GTPase activating protein subunit 2 (non-catalytic) / Q9H2M9* / RAB3 GTPase activating non-catalytic protein subunit 2*  / reaction / complex
 ENSDARG00000056122 gdi1 / GDP dissociation inhibitor 1 / P31150* / P50396* / Rab GDP dissociation inhibitor alpha *  / complex






 

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